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Mouse Anti-KIN Recombinant Antibody (2490D1a) (CBMAB-K0906-LY)

This product is antibody recognizes KIN. The antibody 2490D1a immunoassay techniques such as: Dot Blot, WB.
See all KIN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2490D1a
Antibody Isotype
IgG1
Application
Dot Blot, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kin17 DNA And RNA Binding Protein
Introduction
The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Entrez Gene ID
22944
UniProt ID
O60870
Alternative Names
Kin17 DNA And RNA Binding Protein; KIN; Antigenic Determinant Of RecA Protein Homolog; Binding To Curved DNA; KIN17; BTCD; KIN; Antigenic Determinant Of RecA Protein Homolog (Mouse); Antigenic Determinant Of RecA Protein (Mouse) Homolog; DNA/RNA-Binding Protein KIN17; Rts2;
Function
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity).
Binds via its C-terminal domain to RNA in vitro.
Biological Process
Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIEP:UniProtKB
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus; Cytoplasm. During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.

Huang, X., Dai, Z., Li, Q., Lin, X., Huang, Q., & Zeng, T. (2023). Roles and regulatory mechanisms of KIN17 in cancers. Oncology Letters, 25(4), 1-9.

Peng, P., Wei, W., Lin, S., Li, X., & Lv, J. (2023). KIN17 modulates cell proliferation and migration through the WNT/β-catenin signal pathways in non-small cell lung cancer.

Suzuki, J. M., Osterhoudt, K., Cartwright-Acar, C. H., Gomez, D. R., Katzman, S., & Zahler, A. M. (2022). A genetic screen in C. elegans reveals roles for KIN17 and PRCC in maintaining 5’splice site identity. PLoS Genetics, 18(2), e1010028.

Su, B., Zhong, M., Zhang, Y., Wu, K., Huang, Q., Zhu, C., & Zeng, T. (2022). Deficiency of kin17 facilitates apoptosis of cervical cancer cells by modulating caspase 3, PARP, and Bcl-2 Family Proteins. Journal of Oncology, 2022.

Gaspar, V. P., Ramos, A. C., Cloutier, P., Pattaro Junior, J. R., Duarte Junior, F. F., Bouchard, A., ... & Fernandez, M. A. (2021). Interactome analysis of KIN (Kin17) shows new functions of this protein. Current Issues in Molecular Biology, 43(2), 767-781.

Jiang, Q. G., Xiong, C. F., & Lv, Y. X. (2021). Kin17 facilitates thyroid cancer cell proliferation, migration, and invasion by activating p38 MAPK signaling pathway. Molecular and cellular biochemistry, 476, 727-739.

Lopez, J. M., Osterhoudt, K., Cartwright, C. H., Katzman, S., & Zahler, A. M. (2021). A Genetic Screen for Suppressors of Cryptic 5’Splicing in C. elegans Reveals Roles for KIN17 and PRCC in Maintaining Both 5’and 3’Splice Site Identity. bioRxiv, 2021-06.

Gao, X., Liu, Z., Zhong, M., Wu, K., Zhang, Y., Wang, H., & Zeng, T. (2019). Knockdown of DNA/RNA‑binding protein KIN17 promotes apoptosis of triple‑negative breast cancer cells. Oncology Letters, 17(1), 288-293.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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