KIN

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.

Full Name

Kin17 DNA And RNA Binding Protein

Function

Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity).
Binds via its C-terminal domain to RNA in vitro.

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIEP:UniProtKB
DNA recombinationIEA:UniProtKB-KW
DNA repairIEA:UniProtKB-KW
DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
mRNA processingManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Nucleus; Cytoplasm. During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids.