Sign in or Register   Sign in or Register
  |  

Mouse Anti-KIR2DL2 Recombinant Antibody (DX27) (CBMAB-C1747-CQ)

This product is a mouse antibody that recognizes KIR2DL2. The antibody DX27 can be used for immunoassay techniques such as: FC.
See all KIR2DL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
DX27
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 2
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 2; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 2; P58 Natural Killer Cell Receptor Clone CL-43; Natural Killer-Associated Transcript 6; CD158 Antigen-Like Family Member B1; MHC Class I NK Cell Receptor; P58 NK Receptor CL-43; CD158B1;
Function
Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-264
Cytoplasmic: 265-348

Morales, R., Bolarín, J. M., Muro, M., & Legaz, I. (2023). Presence of KIR2DL2/S2, KIR2DL5, and KIR3DL1 Molecules in Liver Transplant Recipients with Alcoholic Cirrhosis Could Be Implicated in Death by Graft Failure. Diagnostics, 13(7), 1217.

Bortolotti, D., Corazza, M., Rotola, A., Bencivelli, D., Schiuma, G., Danese, E., ... & Borghi, A. (2023). Inhibitory KIR2DL2 receptor and HHV-8 in classic or endemic Kaposi sarcoma. Clinical and Experimental Medicine, 23(1), 79-85.

Fontela, M. G., Snedal, S., & Abate-Daga, D. (2022). 225 Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) immune checkpoint as a modulator of T-cell effector function.

Moradi, S., Stankovic, S., O’connor, G. M., Pymm, P., MacLachlan, B. J., Faoro, C., ... & Vivian, J. P. (2021). Structural plasticity of KIR2DL2 and KIR2DL3 enables altered docking geometries atop HLA-C. Nature Communications, 12(1), 2173.

Marin, M. L. C., Coelho, V., Visentainer, J. E. L., Alves, H. V., Köhler, K. F., Rached, M. R., ... & Kalil, J. (2021). Inhibitory KIR2DL2 gene: risk for deep endometriosis in euro-descendants. Reproductive Sciences, 28(1), 291-304.

Euchner, J., Sprissler, J., Cathomen, T., Fürst, D., Schrezenmeier, H., Debatin, K. M., ... & Felgentreff, K. (2021). Natural killer cells generated from human induced pluripotent stem cells mature to CD56brightCD16+ NKp80+/-in-vitro and express KIR2DL2/DL3 and KIR3DL1. Frontiers in Immunology, 12, 640672.

Deborska-Materkowska, D., Perkowska-Ptasinska, A., Sadowska-Jakubowicz, A., Gozdowska, J., Ciszek, M., Pazik, J., ... & Durlik, M. (2019). Killer immunoglobulin-like receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as genetic markers for stratifying the risk of cytomegalovirus infection in kidney transplant recipients. International Journal of Molecular Sciences, 20(3), 546.

Erbe, A. K., Wang, W., Carmichael, L., Hoefges, A., Grzywacz, B., Reville, P. K., ... & Sondel, P. M. (2019). Follicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab. Journal for immunotherapy of cancer, 7, 1-12.

Saito, H., Umemura, T., Joshita, S., Yamazaki, T., Fujimori, N., Kimura, T., ... & Ota, M. (2018). KIR2DL2 combined with HLA-C1 confers risk of hepatitis C virus-related hepatocellular carcinoma in younger patients. Oncotarget, 9(28), 19650.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-KIR2DL2 Recombinant Antibody (DX27)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare