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Mouse Anti-KIR2DL5A Recombinant Antibody (UP-R1) (CBMAB-C11909-LY)

The product is antibody recognizes KIR2DL5A. The antibody UP-R1 immunoassay techniques such as: FC.
See all KIR2DL5A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
UP-R1
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin, 0.2% BSA
Preservative
0.09% sodium azide
Concentration
5 μL/Test
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
57292
UniProt ID
Q8N109
Alternative Names
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 5A; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A; KIR2DL5; CD158F; Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5; Killer Cell Immunoglobulin-Like Receptor KIR2DL5A;
Function
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Cellular Location
Cell membrane
Topology
Extracellular: 22-238
Helical: 239-259
Cytoplasmic: 260-375
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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