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Rabbit Anti-KIR2DS1 Recombinant Antibody (1127B) (CBMAB-K0106-LY)

This product is antibody recognizes KIR2DS1. The antibody 1127B immunoassay techniques such as: FC.
See all KIR2DS1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
1127B
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
HEK293 human embryonic kidney cell line transfected with human KIR2DS1/CD158h, Met1-His245
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.2% BSA
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 1
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3806
UniProt ID
Q14954
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Short Cytoplasmic Tail 1; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Short Cytoplasmic Tail; 1; MHC Class I NK Cell Receptor Eb6 ActI; CD158 Antigen-Like Family Member H; CD158H; Killer Cell Immunoglobulin-Like Receptor KIRDS1;
Function
Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells.
Biological Process
Immune response1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-264
Cytoplasmic: 265-304

Margolis, D. J., Mitra, N., Hoffstad, O. J., Berna, R., Kim, B. S., Chopra, A., & Phillips, E. J. (2023). Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis. Scientific Reports, 13(1), 1730.

Kaddu-Mulindwa, D., Altmann, B., Robrecht, S., Ziepert, M., Regitz, E., Tausch, E., ... & Rixecker, T. M. (2022). KIR2DS1–HLA-C status as a predictive marker for benefit from rituximab: a post-hoc analysis of the RICOVER-60 and CLL8 trials. The Lancet Haematology, 9(2), e133-e142.

Schetelig, J., Baldauf, H., Heidenreich, F., Massalski, C., Frank, S., Sauter, J., ... & Bornhäuser, M. (2020). External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails. Blood, The Journal of the American Society of Hematology, 135(16), 1386-1395.

Le Luduec, J. B., Boudreau, J. E., Freiberg, J. C., & Hsu, K. C. (2019). Novel approach to cell surface discrimination between KIR2DL1 subtypes and KIR2DS1 identifies hierarchies in NK repertoire, education, and tolerance. Frontiers in Immunology, 10, 734.

Tordai, A., Bors, A., Kiss, K. P., Balassa, K., Andrikovics, H., Batai, A., ... & Masszi, T. (2019). Donor KIR2DS1 reduces the risk of transplant related mortality in HLA-C2 positive young recipients with hematological malignancies treated by myeloablative conditioning. PLoS One, 14(6), e0218945.

Barani, S., Khademi, B., Ashouri, E., & Ghaderi, A. (2018). KIR2DS1, 2DS5, 3DS1 and KIR2DL5 are associated with the risk of head and neck squamous cell carcinoma in Iranians. Human immunology, 79(4), 218-223.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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