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Rabbit Anti-KIR2DS2 Recombinant Antibody (CBLY1-096) (CBMAB-K0929-LY)

This product is antibody recognizes KIR2DS2. The antibody CBLY1-096 immunoassay techniques such as: WB.
See all KIR2DS2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBLY1-096
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 2
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene represents a haplotype-specific family member that encodes a protein with a short cytoplasmic tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Short Cytoplasmic Tail 2; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Short Cytoplasmic Tail; 2; P58 Natural Killer Cell Receptor Clone CL-49; CD158 Antigen-Like Family Member J; MHC Class I NK Cell Receptor; NK Receptor 183 ActI; CD158J; NKAT-5; NKAT5; Killer-Cell Immunoglobulin-Like Receptor Two Domains Short Tail 2 Protein; Killer Cell Immunoglobulin-Like Receptor KIR2DS2; Killer Cell Immunoglobulin-Like Receptor 2DS2;
Function
Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Biological Process
Immune response1 PublicationNAS:UniProtKB
Stimulatory killer cell immunoglobulin-like receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-265
Cytoplasmic: 266-304
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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