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Rabbit Anti-KISS1R (AA 68-119) Recombinant Antibody (CBFYM-1184) (CBMAB-M1341-FY)

This product is rabbit antibody that recognizes KISS1R. The antibody CBFYM-1184 can be used for immunoassay techniques such as: IHC.
See all KISS1R antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYM-1184
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Metastin (1-52)/KiSS-1 (68-119)
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 68-119

Target

Full Name
KISS1 Receptor
Introduction
The protein encoded by this gene is a galanin-like G protein-coupled receptor that binds metastin, a peptide encoded by the metastasis suppressor gene KISS1.
Entrez Gene ID
114229
UniProt ID
B2CP06
Alternative Names
Gpr54; KiSS-1; kiSS-1R
Function
Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.
Biological Process
G protein-coupled receptor signaling pathway1 PublicationNAS:UniProtKB
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Hypogonadotropic hypogonadism 8 with or without anosmia (HH8):
A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Precocious puberty, central 1 (CPPB1):
A condition defined as the development of secondary sexual characteristics in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of puberty in the population. Central precocious puberty results from premature activation of the hypothalamic-pituitary-gonadal axis.
Topology
Extracellular: 1-46
Helical: 47-67
Cytoplasmic: 68-78
Helical: 79-101
Extracellular: 102-120
Helical: 121-138
Cytoplasmic: 139-157
Helical: 158-178
Extracellular: 179-202
Helical: 203-223
Cytoplasmic: 224-263
Helical: 264-284
Extracellular: 285-305
Helical: 306-328
Cytoplasmic: 329-398

Li, Z., Liu, J., Inuzuka, H., & Wei, W. (2022). Functional analysis of the emerging roles for the KISS1/KISS1R signaling pathway in cancer metastasis. Journal of Genetics and Genomics, 49(3), 181-184.

Siahpoosh, Z., Farsimadan, M., Pazhohan, M., Vaziri, H., & Mahmoudi Gomari, M. (2021). KISS1R polymorphism rs587777844 (Tyr313His) is linked to female infertility. British Journal of Biomedical Science, 78(2), 98-100.

Pagani, S., Calcaterra, V., Acquafredda, G., Montalbano, C., Bozzola, E., Ferrara, P., ... & Bozzola, M. (2020). MKRN3 and KISS1R mutations in precocious and early puberty. Italian Journal of Pediatrics, 46(1), 1-6.

Kapustin, R. V., Drobintseva, A. O., Alekseenkova, E. N., Onopriychuk, A. R., Arzhanova, O. N., Polyakova, V. O., & Kvetnoy, I. M. (2020). Placental protein expression of kisspeptin-1 (KISS1) and the kisspeptin-1 receptor (KISS1R) in pregnancy complicated by diabetes mellitus or preeclampsia. Archives of gynecology and obstetrics, 301(2), 437-445.

Moalla, M., Hadj Kacem, F., Al-Mutery, A. F., Mahfood, M., Mejdoub-Rekik, N., Abid, M., ... & Hadj Kacem, H. (2019). Nonstop mutation in the Kisspeptin 1 receptor (KISS1R) gene causes normosmic congenital hypogonadotropic hypogonadism. Journal of assisted reproduction and genetics, 36, 1273-1280.

Ke, R., Ma, X., & Lee, L. T. (2019). Understanding the functions of kisspeptin and kisspeptin receptor (Kiss1R) from clinical case studies. Peptides, 120, 170019.

Cao, Y., Li, Z., Jiang, W., Ling, Y., & Kuang, H. (2019). Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery. Reproductive Biology and Endocrinology, 17, 1-9.

Guzman, S., Brackstone, M., Radovick, S., Babwah, A. V., & Bhattacharya, M. M. (2018). KISS1/KISS1R in cancer: friend or foe?. Frontiers in endocrinology, 9, 437.

Wahab, F., Atika, B., Ullah, F., Shahab, M., & Behr, R. (2018). Metabolic impact on the hypothalamic kisspeptin-kiss1r signaling pathway. Frontiers in endocrinology, 9, 123.

Fratangelo, F., Carriero, M. V., & Motti, M. L. (2018). Controversial role of Kisspeptins/KiSS-1R signaling system in tumor development. Frontiers in endocrinology, 9, 192.

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For research use only. Not intended for any clinical use.

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