Rabbit Anti-KLC3 Recombinant Antibody (CBLY1-106) (CBMAB-K1031-LY)

Name: Rabbit Anti-KLC3 Recombinant Antibody (CBLY1-106)
SKU: CBMAB-K1031-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLY1-106

Application

WB, IHC-P, IP, FC, ICC/IF

Specificity

Mouse, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.098 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kinesin Light Chain 3

Introduction

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	147700
Mouse	232943

UniProt ID

Human	Q6P597
Mouse	Q91W40

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Plays a role during spermiogenesis in the development of the sperm tail midpiece and in the normal function of spermatozoa (By similarity).
May play a role in the formation of the mitochondrial sheath formation in the developing spermatid midpiece (By similarity).

Biological Process

Axo-dendritic transportIEA:Ensembl
Sperm mitochondrial sheath assemblyISS:UniProtKB
Spermatid developmentISS:UniProtKB
SpermatogenesisISS:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton; Mitochondrion. In elongating spermatid tail midpiece, localized in outer dense fibers (ODFs) and associates with mitochondria. Also localizes to the manchette in elongating spermatids.

Daniel-Carlier, N., Castille, J., Passet, B., Vilotte, M., Le Danvic, C., Jaffrezic, F., ... & Vilotte, J. L. (2023). Targeted mutation and inactivation of the kinesin light chain 3 protein-encoding gene have no impact on mouse fertility. Biology of Reproduction, ioad131.

Baek, J. H., Lee, J., Yun, H. S., Lee, C. W., Song, J. Y., Um, H. D., ... & Hwang, S. G. (2018). Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx. Cell Death & Disease, 9(5), 496.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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