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Mouse Anti-KLF6 Recombinant Antibody (9A2) (CBMAB-K1122-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
9A2
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, IHC, WB

Basic Information

Immunogen
Recombinant protein derived from the internal region of the human KLF6 splice variant 1
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.1% sodium azide
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel-like factor 6
Introduction
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009]
Entrez Gene ID
1316
UniProt ID
Q99612
Alternative Names
Kruppel Like Factor 6; Suppressor Of Tumorigenicity 12 Protein; Core Promoter Element-Binding Protein; GC-Rich Sites-Binding Factor GBF; Transcription Factor Zf9; B-Cell-Derived Protein 1; GC-Rich Binding Factor; Proto-Oncogene BCD1; COPEB; BCD1; ST12; CPBP;
Function
Transcriptional activator (By similarity).
Binds a GC box motif. Could play a role in B-cell growth and development.
Biological Process
B cell differentiation1 PublicationNAS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Gastric cancer (GASC):
A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Prostate cancer (PC):
A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
More Infomation

Song, F., Li, S., Dai, X., Yang, F., & Cao, Y. (2023). Activation of KLF6 by titanate nanofibers and regulatory roles of KLF6 on ATF3 in the endothelial monolayer and mouse aortas. Molecular Omics, 19(2), 150-161.

Piret, S. E. (2023). Roles of Krüppel-like transcription factors KLF6 and KLF15 in proximal tubular metabolism. Nephron.

Xiong, Q., Zhang, Z., Yang, Y., Xu, Y., Zhou, Y., Zhang, S., ... & Zhu, Q. (2022). Krüppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3. Journal of Clinical Medicine, 12(1), 200.

León, X., Venegas, M., Pujol, A., Bulboa, C., Llansana, A., Casasayas, M., ... & Camacho, M. (2021). Predictive value of transcriptional expression of Krüppel-like factor-6 (KLF6) in head and neck carcinoma patients treated with radiotherapy. Clinical and Translational Oncology, 23(12), 2507-2512.

Hu, K., Zheng, Q. K., Ma, R. J., Ma, C., Sun, Z. G., & Zhang, N. (2021). Krüppel-like factor 6 splice variant 1: an oncogenic transcription factor involved in the progression of multiple malignant tumors. Frontiers in Cell and Developmental Biology, 9, 661731.

Syafruddin, S. E., Mohtar, M. A., Wan Mohamad Nazarie, W. F., & Low, T. Y. (2020). Two sides of the same coin: the roles of KLF6 in physiology and pathophysiology. Biomolecules, 10(10), 1378.

Syafruddin, S. E., Rodrigues, P., Vojtasova, E., Patel, S. A., Zaini, M. N., Burge, J., ... & Vanharanta, S. (2019). A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma. Nature communications, 10(1), 1152.

Babaei, K., Khaksar, R., Zeinali, T., Hemmati, H., Bandegi, A., Samidoust, P., ... & Norollahi, S. E. (2019). Epigenetic profiling of MUTYH, KLF6, WNT1 and KLF4 genes in carcinogenesis and tumorigenesis of colorectal cancer. BioMedicine, 9(4).

Kim, G. D., Ng, H. P., Patel, N., & Mahabeleshwar, G. H. (2019). Kruppel-like factor 6 and miR-223 signaling axis regulates macrophage-mediated inflammation. The FASEB Journal, 33(10), 10902.

Wang, Z., Mehra, V., Simpson, M. T., Maunze, B., Chakraborty, A., Holan, L., ... & Venkatesh, I. (2018). KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons. Scientific Reports, 8(1), 12565.

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For research use only. Not intended for any clinical use.

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