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Mouse Anti-KLF9 Recombinant Antibody (2B9) (CBMAB-K1132-LY)

This product is antibody recognizes KLF9. The antibody 2B9 immunoassay techniques such as: ELISA.
See all KLF9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B9
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
KLF9 (NP_001197, 25 a.a. ~ 102 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel-like factor 9
Introduction
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Entrez Gene ID
687
UniProt ID
Q13886
Alternative Names
Kruppel Like Factor 9; Basic Transcription Element-Binding Protein 1; Transcription Factor BTEB1; GC-Box-Binding Protein 1; BTE-Binding Protein 1; BTEB1; BTEB; Basic Transcription Element Binding Protein 1; Krueppel-Like Factor 9;
Function
Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation (PubMed:22711835).
Biological Process
Cellular response to cortisol stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to thyroid hormone stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Circadian rhythmManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Wang, T., Feng, L., Shi, Z., Yang, L., Yu, X., Wu, J., ... & Wang, W. (2023). A negative feedback loop between KLF9 and the EMT program dictates metastasis of hepatocellular carcinoma. Journal of Cellular and Molecular Medicine, 27(16), 2372-2384.

Bernhardt, C., Sock, E., Fröb, F., Hillgärtner, S., Nemer, M., & Wegner, M. (2022). KLF9 and KLF13 transcription factors boost myelin gene expression in oligodendrocytes as partners of SOX10 and MYRF. Nucleic Acids Research, 50(20), 11509-11528.

Qu, R., Liu, J., Feng, L., Li, L., Liu, J., Sun, F., & Sun, L. (2022). Down-regulation of KLF9 ameliorates LPS-caused acute lung injury and inflammation in mice via reducing GSDMD expression. Autoimmunity, 55(8), 587-596.

Gans, I. M., Grendler, J., Babich, R., Jayasundara, N., & Coffman, J. A. (2021). Glucocorticoid-responsive transcription factor Krüppel-like factor 9 regulates fkbp5 and metabolism. Frontiers in Cell and Developmental Biology, 9, 727037.

Sweet, D. R., Fan, L., & Jain, M. K. (2019). Taking KLF9 to “Cort” for crimes against metabolism. The Journal of Clinical Investigation, 129(6), 2178-2180.

Zhong, Z., Zhou, F., Wang, D., Wu, M., Zhou, W., Zou, Y., ... & Yin, X. (2018). Expression of KLF9 in pancreatic cancer and its effects on the invasion, migration, apoptosis, cell cycle distribution, and proliferation of pancreatic cancer cell lines. Oncology reports, 40(6), 3852-3860.

Ji, P., Fan, X., Ma, X., Wang, X., Zhang, J., & Mao, Z. (2018). Krüppel-like factor 9 suppressed tumorigenicity of the pancreatic ductal adenocarcinoma by negatively regulating frizzled-5. Biochemical and biophysical research communications, 499(4), 815-821.

Bai, X. Y., Li, S., Wang, M., Li, X., Yang, Y., Xu, Z., ... & Wu, H. (2018). Krüppel-like factor 9 down-regulates matrix metalloproteinase 9 transcription and suppresses human breast cancer invasion. Cancer letters, 412, 224-235.

Otsuka, K., Takehara, A., Chiba, N., & Matsui, Y. (2018). Identification of KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells. PloS one, 13(10), e0205004.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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