Mouse Anti-KLHL17 Recombinant Antibody (CBLY1-116) (CBMAB-K1182-LY)

This product is antibody recognizes KLHL17. The antibody CBLY1-116 immunoassay techniques such as: WB, IP, IF, ELISA.
See all KLHL17 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBLY1-116

Antibody Isotype

IgG

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Kelch Like Family Member 17

Introduction

The protein encoded by this gene is expressed in neurons of most regions of the brain. It contains an N-terminal BTB domain, which mediates dimerization of the protein, and a C-terminal Kelch domain, which mediates binding to F-actin. This protein may play a key role in the regulation of actin-based neuronal function. [provided by RefSeq, Aug 2010]

Entrez Gene ID

339451

UniProt ID

Q6TDP4

Alternative Names

Kelch Like Family Member 17; Actinfilin; Kelch-Like 17 (Drosophila); Kelch-Like Protein 17; Kelch-Like 17;

Function

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).

Biological Process

Actin cytoskeleton organizationISS:UniProtKB
Brain developmentManual Assertion Based On ExperimentIBA:GO_Central
Protein ubiquitinationIEA:UniProtKB-UniPathway

Cellular Location

Cell junction, synapse, postsynaptic density; Cell junction, synapse

References

Hu, H. T., Lin, Y. J., Wang, U. T. T., Lee, S. P., Liou, Y. H., Chen, B. C., & Hsueh, Y. P. (2023). Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus. Plos Biology, 21(8), e3002274.

Liu, Z., Zhao, M., Jiang, X., Zhang, Y., Zhang, S., Xu, Y., ... & Qiu, X. (2022). Upregulation of KLHL17 promotes the proliferation and migration of non-small cell lung cancer by activating the Ras/MAPK signaling pathway. Laboratory Investigation, 102(12), 1389-1399.

Hu, H. T., Huang, T. N., & Hsueh, Y. P. (2020). KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms and autism, regulates dendritic spine enlargement. Journal of Biomedical Science, 27(1), 1-18.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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