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Rabbit Anti-KLLN Recombinant Antibody (CBLY1-127) (CBMAB-K1393-LY)

This product is antibody recognizes KLLN. The antibody CBLY1-127 immunoassay techniques such as: WB.
See all KLLN antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBLY1-127
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killin, P53 Regulated DNA Replication Inhibitor
Introduction
The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]
Entrez Gene ID
Human100144748
Rat102551694
UniProt ID
HumanB2CW77
Function
DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.
Biological Process
Apoptotic processIEA:UniProtKB-KW
Cell cycleIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Cowden syndrome 4 (CWS4):
A form of Cowden syndrome, a hamartomatous polyposis syndrome with age-related penetrance. Cowden syndrome is characterized by hamartomatous lesions affecting derivatives of ectodermal, mesodermal and endodermal layers, macrocephaly, facial trichilemmomas (benign tumors of the hair follicle infundibulum), acral keratoses, papillomatous papules, and elevated risk for development of several types of malignancy, particularly breast carcinoma in women and thyroid carcinoma in both men and women. Colon cancer and renal cell carcinoma have also been reported. Hamartomas can be found in virtually every organ, but most commonly in the skin, gastrointestinal tract, breast and thyroid.

Gao, L., Shao, X., Yue, Q., Wu, W., Yang, X., He, X., ... & Zhang, R. (2021). circAMOTL1L suppresses renal cell carcinoma growth by modulating the miR-92a-2-5p/KLLN pathway. Oxidative Medicine and Cellular Longevity, 2021.

Razavi, S. A., Salehipour, P., Gholami, H., Sheikholeslami, S., Zarif-Yeganeh, M., Yaghmaei, P., ... & Hedayati, M. (2021). New evidence on tumor suppressor activity of PTEN and KLLN in papillary thyroid carcinoma. Pathology-Research and Practice, 225, 153586.

Sankunny, M., & Eng, C. (2020). Identification of nuclear export signal in KLLN suggests potential role in proteasomal degradation in cancer cells. Oncotarget, 11(50), 4625.

Wang, C., Zong, J., Li, Y., Wang, X., Du, W., & Li, L. (2019). MiR‐744‐3p regulates keratinocyte proliferation and differentiation via targeting KLLN in psoriasis. Experimental Dermatology, 28(3), 283-291.

Liu, H., Xiong, W., Liu, F., Lin, F., He, J., Liu, C., ... & Dong, S. (2019). Significant role and mechanism of microRNA-143-3p/KLLN axis in the development of coronary heart disease. American Journal of Translational Research, 11(6), 3610.

Chen, R., Wang, M., Fu, S., Cao, F., Duan, P., & Lu, J. (2019). MicroRNA‑204 may participate in the pathogenesis of hypoxic‑ischemic encephalopathy through targeting KLLN. Experimental and Therapeutic Medicine, 18(5), 3299-3306.

Sankunny, M., & Eng, C. (2018). KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell Death Discovery, 4(1), 92.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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