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Mouse Anti-KNSTRN Recombinant Antibody (CBXS-2208) (CBMAB-S4970-CQ)

This product is a mouse antibody that recognizes KNSTRN. The antibody CBXS-2208 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all KNSTRN antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXS-2208
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
kinetochore-localized astrin/SPAG5 binding
Introduction
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).
Entrez Gene ID
Rat311325
Mouse51944
UniProt ID
RatQ6AXN6
MouseQ9D9Z1
Alternative Names
1700025D04Rik; C15orf23; D2Ertd750e; SKAP; Traf4af1
Function
Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759).
Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139).
The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792).
Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123).
May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257).
Biological Process
Cell divisionIEA:UniProtKB-KW
Cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Cellular response to epidermal growth factor stimulusManual Assertion Based On ExperimentIMP:ARUK-UCL
Chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule cytoskeleton organizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Mitotic sister chromatid segregationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIMP:UniProtKB
Spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle pole
Cytoplasm, cytoskeleton, microtubule organizing center
Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends (PubMed:23035123).
Involvement in disease
Roifman-Chitayat syndrome (ROCHIS):
An autosomal recessive digenic disorder characterized by global developmental delay, variable neurologic features such as seizures and ataxia, optic atrophy, dysmorphic facial features, distal skeletal anomalies, and recurrent invasive infections due to combined immunodeficiency.
Cutaneous squamous cell carcinomas (SCC): A malignancy of the skin. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. Disease susceptibility is associated with variants affecting the gene represented in this entry. Variant Phe-24 appears specific for UV-associated malignancies (PubMed:25194279).

Zhang, W., Liao, Y., Liu, C., Liu, L., & Zhou, X. (2023). KNSTRN, a Poor Prognostic Biomarker, Affects the Tumor Immune Microenvironment and Immunotherapy Outcomes in Pan-Cancer. Disease Markers, 2023.

Xiao, S., Zou, Y., Wang, L., Wang, Q., & Wang, T. (2023). Pan-cancer analysis and KNSTRN as a potential prognosis biomarker.

Jin, L., Zhang, X., Fan, M., Li, W., Lai, Q., Peng, W., & Zhang, X. (2023). Comprehensive Analysis of KNSTRN Immunoassays and KNSTRN-related ceRNA Network in Hepatocellular Carcinoma.

Jin, L., Zhang, X., Fan, M., Li, W., Lai, Q., Peng, W., & Zhang, X. (2023). NamiRNA-mediated high expression of KNSTRN correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma.

Deng, P., Zhou, R., Zhang, J., & Cao, L. (2021). Increased expression of KNSTRN in lung adenocarcinoma predicts poor prognosis: a bioinformatics analysis based on TCGA data. Journal of Cancer, 12(11), 3239.

Xiong, Y., Ju, L., Yuan, L., Chen, L., Wang, G., Xu, H., ... & Wang, X. (2021). KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer. Oncogene, 40(9), 1595-1608.

Schmitz, L., Grinblat, B., Novak, B., Hoeh, A. K., Händschke, K., von Dobbeler, C., ... & Dirschka, T. (2019). Somatic mutations in kinetochore gene KNSTRN are associated with basal proliferating actinic keratoses and cutaneous squamous cell carcinoma. Journal of the European Academy of Dermatology and Venereology, 33(8), 1535-1540.

Ma, S., & Xie, C. (2019). P1. 01-137 KNSTRN Promotes Non-Small Cell Lung Cancer Progress and Attenuates Radiosensitivity via Activating EGFR-ERK1/2-E2F1 Pathway. Journal of Thoracic Oncology, 14(10), S417.

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For research use only. Not intended for any clinical use.

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