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Rat Anti-KPNA4 Recombinant Antibody (3D10) (CBMAB-K1480-LY)


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Summary

Host Animal
Rat
Specificity
Mouse, Rat, Hamster, Cattle, Dog, Human, Monkey
Clone
3D10
Antibody Isotype
IgG2a
Application
WB, ELISA

Basic Information

Specificity
Mouse, Rat, Hamster, Cattle, Dog, Human, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Introduction
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3840
Mouse16649
Rat361959
Monkey702486
Cattle535090
Hamster100757318
Dog478680
UniProt ID
HumanO00629
MouseO35343
RatQ56R17
MonkeyA0A2K5WX73
CattleA0A3S5ZPE0
HamsterA0A3Q0DIG1
DogE2RPB3
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Biological Process
NLS-bearing protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
More Infomation

Yang, W., Yao, Y., Yang, S., & Ke, Y. (2023). Circular RNA hsa_circ_0008003 promotes the progression of non–small‐cell lung cancer by sponging miR‐548I and regulating KPNA4 expression. Thoracic Cancer, 14(6), 544-554.

Bao, J., Xu, C., Li, B., Wu, Z., Shen, J., Song, P., ... & Hu, G. (2022). Systematic Characterization of the Clinical Relevance of KPNA4 in Pancreatic Ductal Adenocarcinoma. Frontiers in Oncology, 12, 834728.

Li, J., Fan, R., & Xiao, H. (2021). Circ_ZFR contributes to the paclitaxel resistance and progression of non-small cell lung cancer by upregulating KPNA4 through sponging miR-195-5p. Cancer cell international, 21, 1-15.

Xu, M., Liang, H., Li, K., Zhu, S., Yao, Z., Xu, R., & Lin, N. (2021). Value of KPNA4 as a diagnostic and prognostic biomarker for hepatocellular carcinoma. Aging (Albany NY), 13(4), 5263.

Feng, L., Wang, R., Yang, Y., Shen, X., Shi, Q., Lian, M., ... & Fang, J. (2021). KPNA4 regulated by miR-548b-3p promotes the malignant phenotypes of papillary thyroid cancer. Life sciences, 265, 118743.

Li, X., Su, Y., Li, N., Zhang, F. R., & Zhang, N. (2021). Berberine attenuates MPP+-Induced neuronal injury by regulating LINC00943/miR-142-5p/KPNA4/NF-κB pathway in SK-N-SH cells. Neurochemical Research, 46(12), 3286-3300.

Ping, X., Cheng, Y., Bao, J., Shi, K., Zou, J., & Shentu, X. (2021). KPNA4 is involved in cataract formation via the nuclear import of p53. Gene, 786, 145621.

Yan, J., Fang, T., Zhang, M., & Zhou, Q. (2021). LINC00467 facilitates osteosarcoma progression by sponging miR‑217 to regulate KPNA4 expression. International Journal of Molecular Medicine, 47(3), 1-1.

Hu, R. H., Zhang, Z. T., Wei, H. X., Ning, L., Ai, J. S., Li, W. H., ... & Wang, S. Q. (2020). LncRNA ST7-AS1, by regulating miR-181b-5p/KPNA4 axis, promotes the malignancy of lung adenocarcinoma. Cancer cell international, 20, 1-15.

Li, X., Yu, M., & Yang, C. (2020). YY1‐mediated overexpression of long noncoding RNA MCM3AP‐AS1 accelerates angiogenesis and progression in lung cancer by targeting miR‐340‐5p/KPNA4 axis. Journal of cellular biochemistry, 121(3), 2258-2267.

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For research use only. Not intended for any clinical use.

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