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Mouse Anti-KRT10 Recombinant Antibody (CBYY-C2816) (CBMAB-C4257-YY)

This product is mouse antibody that recognizes KRT10. The antibody CBYY-C2816 can be used for immunoassay techniques such as: IHC, WB
See all KRT10 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Human, Rabbit, Rat
Clone
CBYY-C2816
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Human skin cell preparation
Specificity
Cattle, Dog, Human, Rabbit, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Culture supernatant
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 10
Entrez Gene ID
Human3858
Rat450225
Rabbit100009029
Cattle281888
Dog491006
UniProt ID
HumanP13645
RatQ6IFW6
RabbitG1T1V0
CattleP06394
DogQ6EIY9
Alternative Names
B-CK, BCKB, CPK-B, HEL-211, HEL-S-29, CKB
Function
Plays a role in the establishment of the epidermal barrier on plantar skin.
(Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.
(Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
Biological Process
Keratinocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Peptide cross-linkingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of epidermis developmentISS:UniProtKB
Protein heterotetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted, extracellular space
Cell surface
Localized on the surface of desquamated nasal epithelial cells (PubMed:12427098).
Localized on the surface of lung cell lines (PubMed:19627498).
Involvement in disease
Epidermolytic hyperkeratosis (EHK):
An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Ichthyosis annular epidermolytic (AEI):
A skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Erythroderma, ichthyosiform, congenital reticular (CRIE):
A rare skin condition characterized by slowly enlarging islands of normal skin surrounded by erythematous ichthyotic patches in a reticulated pattern. The condition starts in infancy as a lamellar ichthyosis, with small islands of normal skin resembling confetti appearing in late childhood and at puberty. Histopathologic findings include band-like parakeratosis, psoriasiform acanthosis, and vacuolization of keratinocytes with binucleated cells in the upper epidermis, sometimes associated with amyloid deposition in the dermis. Ultrastructural abnormalities include perinuclear shells formed from a network of fine filaments in the upper epidermis.

Knight, L. K., McGrath, J., Ozoemena, L., Roberts, R., & Hlela, C. (2023). A new heterozygous frameshift variant in keratin 10 resulting in ichthyosis hystrix in a father and daughter. JAAD Case Reports, 35, 22-24.

Takeichi, T., Yasushi, S. U. G. A., Mizuno, T., Okuno, Y., Ichikawa, D., Michihiro, K. O. N. O., ... & Akiyama, M. (2020). Recurrent KRT10 variant in ichthyosis with confetti. Acta Dermato-Venereologica, 100(14).

Pan, Y., Feng, C., Wang, H., Lee, M., Tang, Z., & Lin, Z. (2020). Ichthyosis with confetti caused by new and recurrent mutations in KRT10 associated with varying degrees of keratin 10 mis-localization. Journal of Dermatological Science, 98(1), 35-40.

Kim, J., & Villadsen, R. (2020). The expression pattern of epidermal differentiation marker Keratin 10 in the normal human breast and breast cancer cells. Journal of Histochemistry & Cytochemistry, 68(8), 561-570.

March, O. P., Lettner, T., Klausegger, A., Ablinger, M., Kocher, T., Hainzl, S., ... & Reichelt, J. (2019). Gene Editing–Mediated Disruption of Epidermolytic Ichthyosis–Associated KRT10 Alleles Restores Filament Stability in Keratinocytes. Journal of Investigative Dermatology, 139(8), 1699-1710.

Terrinoni, A., Didona, B., Caporali, S., Chillemi, G., Lo Surdo, A., Paradisi, M., ... & Melino, G. (2018). Role of the keratin 1 and keratin 10 tails in the pathogenesis of ichthyosis hystrix of Curth Macklin. PLoS One, 13(4), e0195792.

Komori, T., Ono, M., Hara, E. S., Ueda, J., Nguyen, H. T. T., Nguyen, H. T., ... & Oohashi, T. (2018). Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Scientific reports, 8(1), 2612.

Vodo, D., Sarig, O., Peled, A., Samuelov, L., Malchin, N., Grafi‐Cohen, M., & Sprecher, E. (2018). Recessive epidermolytic ichthyosis results from loss of keratin 10 expression, regardless of the mutation location. Clinical and Experimental Dermatology, 43(2), 187-190.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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