Mouse Anti-KRT13 Recombinant Antibody (CBYY-C2819) (CBMAB-C4260-YY)

This product is mouse antibody that recognizes KRT13. The antibody CBYY-C2819 can be used for immunoassay techniques such as: FC, ICC, IF, IHC-P, WB
See all KRT13 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Horse, Human, Rabbit

Clone

CBYY-C2819

Antibody Isotype

IgG1

Application

FC, ICC, IF, IHC-P, WB

Basic Information

Immunogen

Solubilized keratin extracted from human stratum corneum

Specificity

Horse, Human, Rabbit

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

PBS

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Keratin 13

Entrez Gene ID

Human	3860
Horse	100066675
Rabbit	100344183

UniProt ID

Human

P13646

Biological Process

Cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytosol
Extracellular exosome
Intermediate filament cytoskeleton
Keratin filament
Nucleus

Involvement in disease

White sponge nevus 2 (WSN2):
A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

PTM

O-glycosylated; glycans consist of single N-acetylglucosamine residues.

References

Yin, L., Li, Q., Mrdenovic, S., Chu, G. C. Y., Wu, B. J., Bu, H., ... & Chung, L. W. (2022). KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway. Breast Cancer Research, 24(1), 1-13.

Simonson, L., Vold, S., Mowers, C., Massey, R. J., Ong, I. M., Longley, B. J., & Chang, H. (2020). Keratin 13 deficiency causes white sponge nevus in mice. Developmental biology, 468(1-2), 146-153.

Yin, L., Chu, G. C. Y., Li, Q., Yin, L., Lewis, M., Tighiouart, M., ... & Zhau, H. E. (2018). KRT13 promotes stemness and drives metastasis in breast cancer through direct interaction with plakoglobin-desmoplakin complexes regulating c-Myc signaling pathway. Cancer Research, 78(13_Supplement), 5002-5002.

Westin, M., Rekabdar, E., Blomstrand, L., Klintberg, P., Jontell, M., & Robledo‐Sierra, J. (2018). Mutations in the genes for keratin‐4 and keratin‐13 in Swedish patients with white sponge nevus. Journal of Oral Pathology & Medicine, 47(2), 152-157.

Hatta, M., Miyake, Y., Uchida, K., & Yamazaki, J. (2018). Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line. Biochemical and biophysical research communications, 496(2), 381-386.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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