Sign in or Register   Sign in or Register
  |  

Mouse Anti-KRT14 Recombinant Antibody (CBYY-C2822) (CBMAB-C4263-YY)

This product is mouse antibody that recognizes KRT14. The antibody CBYY-C2822 can be used for immunoassay techniques such as: FC, ICC, IHC, WB
See all KRT14 antibodies

Summary

Host Animal
Mouse
Specificity
Dog, Human, Pig, Rat
Clone
CBYY-C2822
Antibody Isotype
IgG3
Application
FC, ICC, IHC, WB

Basic Information

Immunogen
Cytokeratin 14
Specificity
Dog, Human, Pig, Rat
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
1 mg/mL
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Keratin 14
Entrez Gene ID
Human3861
Rat287701
Dog100685323
Pig100737113
UniProt ID
HumanP02533
RatQ6IFV1
DogF1Q0R0
PigF1S0J8
Alternative Names
CREB; CREB-1
Function
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Epithelial cell differentiationIEA:Ensembl
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Intermediate filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Expressed in both as a filamentous pattern.
Involvement in disease
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS):
A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Epidermolysis bullosa simplex, Koebner type (K-EBS):
A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1):
A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma.
Naegeli-Franceschetti-Jadassohn syndrome (NFJS):
A rare autosomal dominant form of ectodermal dysplasia. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), palmoplantar keratoderma, hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, and tooth enamel defects.
Dermatopathia pigmentosa reticularis (DPR):
A rare ectodermal dysplasia characterized by lifelong persistent reticulate hyperpigmentation, non-cicatricial alopecia, and nail dystrophy. Variable features include adermatoglyphia, hypohidrosis or hyperhidrosis, and palmoplantar hyperkeratosis.
PTM
A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.
Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KRT14 Recombinant Antibody (CBYY-C2822)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare