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Rabbit Anti-KRT15 Recombinant Antibody (EP14) (CBMAB-K1635-LY)

This product is antibody recognizes KRT15. The antibody EP14 immunoassay techniques such as: IHC-Fr, IHC-P.
See all KRT15 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EP14
Antibody Isotype
IgG
Application
IHC-Fr, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 15
Introduction
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region on chromosome 17q21.2. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3866
UniProt ID
P19012
Alternative Names
Keratin 15; Type I Cytoskeletal 15; Keratin 15; Type I; Keratin-15; Basic; Keratin-15; Beta; Cytokeratin 15; CK-15; K15;
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytosol
Extracellular exosome
Intermediate filament

Zhu, W., Han, L., Wu, Y., Tong, L., He, L., Wang, Q., ... & Zhou, J. (2023). Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9. Respiratory Research, 24(1), 1-16.

Zhang, W., Chen, P., Li, Z., Zhang, R., & Zhang, J. (2023). Clinical implication of keratin-15 quantification for renal cell carcinoma management: its dysregulation and association with clinicopathologic characteristics and prognostication. The Tohoku Journal of Experimental Medicine, 260(2), 99-107.

Ievlev, V., Lynch, T. J., Freischlag, K. W., Gries, C. B., Shah, A., Pai, A. C., ... & Parekh, K. R. (2023). Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells. JCI insight, 8(2).

Yang, X., Liu, Z., Wang, X., Han, Z., Zhang, C., & Guo, L. (2023). Tumor keratin 15 expression links with less extent of invasion and better prognosis in papillary thyroid cancer patients receiving tumor resection. Irish Journal of Medical Science (1971-), 1-7.

Wang, J., & Zhu, G. (2023). Silencing of keratin 15 impairs viability and mobility while facilitating the doxorubicin chemosensitivity by inactivating the β‑catenin pathway in liver cancer. Oncology Letters, 26(4), 1-8.

Kohler, K. T., Goldhammer, N., Demharter, S., Pfisterer, U., Khodosevich, K., Rønnov-Jessen, L., ... & Kim, J. (2022). Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature. NPJ Breast Cancer, 8(1), 81.

Zhong, P., Shu, R., Wu, H., Liu, Z., Shen, X., & Hu, Y. (2021). Low KRT15 expression is associated with poor prognosis in patients with breast invasive carcinoma. Experimental and Therapeutic Medicine, 21(4), 1-1.

Rao, X., Wang, J., Song, H. M., Deng, B., & Li, J. G. (2020). KRT15 overexpression predicts poor prognosis in colorectal cancer. Neoplasma, 67(2), 410-414.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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