Mouse Anti-KRT17 Recombinant Antibody (A797) (CBMAB-AP4157LY)

Name: Mouse Anti-KRT17 Recombinant Antibody (A797)
SKU: CBMAB-AP4157LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A797

Application

ELISA, IP, WB

Immunogen

Synthetic Peptide

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

keratin 17

Introduction

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

Entrez Gene ID

3872

UniProt ID

Q04695

Alternative Names

Keratin 17; Keratin 17, Type I; Cytokeratin-17; CK-17; 39.1; K17;

Function

CSB-MA000239

Biological Process

Hair follicle morphogenesisISS:UniProtKB
Intermediate filament organizationIEA:Ensembl
KeratinizationIEA:Ensembl
Positive regulation of cell growthIEA:Ensembl
Positive regulation of hair follicle developmentIEA:Ensembl
Positive regulation of translationIEA:Ensembl

Cellular Location

Cytoplasm

Involvement in disease

Pachyonychia congenita 2 (PC2):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma and hyperhidrosis, follicular hyperkeratosis, multiple epidermal cysts, absent/sparse eyebrow and body hair, and by the presence of natal teeth.
Steatocystoma multiplex (SM):
Disease characterized by round or oval cystic tumors widely distributed on the back, anterior trunk, arms, scrotum, and thighs.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

PTM

Phosphorylation at Ser-44 ^oCcurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Zhang, H., Zhang, Y., Feng, Z., Lu, L., Li, Y., Liu, Y., & Chen, Y. (2022). Analysis of the Expression and Role of Keratin 17 in Human Tumors. Frontiers in Genetics, 13, 801698.

Li, M., Rao, X., Cui, Y., Zhang, L., Li, X., Wang, B., ... & Zhuo, W. (2022). The keratin 17/YAP/IL6 axis contributes to E-cadherin loss and aggressiveness of diffuse gastric cancer. Oncogene, 41(6), 770-781.

Li, C., Teng, Y., Wu, J., Yan, F., Deng, R., Zhu, Y., & Li, X. (2021). A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors. Translational cancer research, 10(10), 4489.

Ji, R., Ji, Y., Ma, L., Ge, S., Chen, J., Wu, S., ... & Liu, Z. (2021). Keratin 17 upregulation promotes cell metastasis and angiogenesis in colon adenocarcinoma. Bioengineered, 12(2), 12598-12611.

Jacob, J. T., Nair, R. R., Poll, B. G., Pineda, C. M., Hobbs, R. P., Matunis, M. J., & Coulombe, P. A. (2020). Keratin 17 regulates nuclear morphology and chromatin organization. Journal of cell science, 133(20), jcs254094.

Liu, Z., Yu, S., Ye, S., Shen, Z., Gao, L., Han, Z., ... & Kang, M. (2020). Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma. Journal of proteomics, 211, 103557.

Yang, L., Zhang, S., & Wang, G. (2019). Keratin 17 in disease pathogenesis: from cancer to dermatoses. The Journal of pathology, 247(2), 158-165.

Liu, J., Liu, L., Cao, L., & Wen, Q. (2018). Keratin 17 promotes lung adenocarcinoma progression by enhancing cell proliferation and invasion. Medical science monitor: international medical journal of experimental and clinical research, 24, 4782.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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