Mouse Anti-KRT40 Recombinant Antibody (AE13) (CBMAB-H3648-FY)

This product is mouse antibody that recognizes KRT40. The antibody AE13 can be used for immunoassay techniques such as: IHC-P, WB, IHC-Fr, FC.
See all KRT40 antibodies

Published Data

Fig.1 DAPI-stained sections were co-stained with markers for bulge and SHG (KRT15), proliferation (Ki67), inner root sheath (IRS) (AE15), hair shaft (HS) precursors (AE13), dermal sheath (SMA), outer root sheath (ORS) (KRT14), isthmus (LRIG1), sebaceous gland (SG) (FAS, FABP) as indicated.

Fig.2 BrdU staining showing reduced proliferation in the matrix (Mx) of P14 gPRC2-null HFs; quantification of percentage of BrdU(+) matrix cells (n=3; gEEDcKO, p=0.0083; gSuz12cKO, p<0.0001). AE13 marks matrix limit.

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Human

Clone

AE13

Antibody Isotype

Application

IHC-P, WB, IHC-Fr, FC

Basic Information

Immunogen

Human hair keratins

Specificity

Mouse, Human

Antibody Isotype

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.1% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Keratin 40

Introduction

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21.

Entrez Gene ID

Human	125115
Mouse	406221

UniProt ID

Human	Q6A162
Mouse	Q6IFX3

Alternative Names

Keratin 40; Keratin 40, Type I; Cytokeratin-40; CK-40; KA36; K40

Function

May play a role in late hair differentiation.

Cellular Location

Cytosol
Intermediate filament

References

Ho, M., Thompson, B., Fisk, J. N., Nebert, D. W., Bruford, E. A., Vasiliou, V., & Bunick, C. G. (2022). Update of the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disorders. Human Genomics, 16(1), 1-21.

Bao, Q., Zhang, X., Bao, P., Liang, C., Guo, X., Yin, M., ... & Yan, P. (2022). Genome-wide identification, characterization, and expression analysis of keratin genes (KRTs) family in yak (Bos grunniens). Gene, 818, 146247.

Ehrlich, F., Laggner, M., Langbein, L., Burger, P., Pollreisz, A., Tschachler, E., & Eckhart, L. (2019). Comparative genomics suggests loss of keratin K24 in three evolutionary lineages of mammals. Scientific reports, 9(1), 10924.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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