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Mouse Anti-KRT7 Recombinant Antibody (CB302) (CBMAB-CS302LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CB302
Application
WB, IHC, IP
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence of human Cytokeratin 7.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
30% glycerol
Preservative
0.01% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Keratin 7
Introduction
Keratin 7; Sarcolectin; Keratin, 55K Type II Cytoskeletal; Keratin, Type II Cytoskeletal 7; Type-II Keratin Kb7; Keratin 7, Type II; Cytokeratin 7; CK-7; SCL;
Entrez Gene ID
Human3855
Rat300242
Mouse110310
UniProt ID
HumanP08729
RatQ6IG12
MouseQ9DCV7
Alternative Names
SCL; Keratin type II cytoskeletal 7; Cytokeratin-7; CK-7; Keratin-7; K7; Sarcolectin; Type-II keratin Kb7
Function
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).
Cellular Location
Cytoplasm
PTM
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

Zhao, Z., Meng, M., Yao, J., Zhou, H., Chen, Y., Liu, J., ... & Zhou, Q. (2023). The long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers. Cell Death & Disease, 14(4), 293.

Dariane, C., Clairefond, S., Péant, B., Communal, L., Thian, Z., Ouellet, V., ... & Saad, F. (2022). High Keratin-7 Expression in Benign Peri-Tumoral Prostatic Glands Is Predictive of Bone Metastasis Onset and Prostate Cancer-Specific Mortality. Cancers, 14(7), 1623.

Lin, M., Wang, J., Wang, S., & Huang, Y. (2022). Expression level of keratin 7 in epithelial ovarian cancer and malignant metastasis of benign epithelial ovarian tumors. Cellular and Molecular Biology, 68(2), 153-161.

Communal, L., Roy, N., Cahuzac, M., Rahimi, K., Köbel, M., Provencher, D. M., & Mes-Masson, A. M. (2021). A Keratin 7 and E-Cadherin Signature Is Highly Predictive of Tubo-Ovarian High-Grade Serous Carcinoma Prognosis. International Journal of Molecular Sciences, 22(10), 5325.

An, Q., Liu, T., Wang, M. Y., Yang, Y. J., Zhang, Z. D., Liu, Z. J., & Yang, B. (2021). KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway. Oncology reports, 45(2), 481-492.

Li, Y., Su, Z., Wei, B., & Liang, Z. (2021). KRT7 overexpression is associated with poor prognosis and immune cell infiltration in patients with pancreatic adenocarcinoma. International Journal of General Medicine, 2677-2694.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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