Mouse Anti-KRT71 Recombinant Antibody (1D4) (CBMAB-K1988-LY)

Name: Mouse Anti-KRT71 Recombinant Antibody (1D4)
SKU: CBMAB-K1988-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D4

Application

ELISA, WB

Immunogen

KRT71 (NP_258259.1, 251 a.a. ~ 332 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: LQAKVESMDQ EIKFFRCLFE AEITQIQSHI SDMSVILSMD NNRNLDLDSI IDEVRTQYEE IALKSKAEAE ALYQTKFQEL QL

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

keratin 71

Introduction

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Entrez Gene ID

112802

UniProt ID

Q3SY84

Alternative Names

Keratin 71; Type II Inner Root Sheath-Specific Keratin-K6irs1; Type-II Keratin Kb34; Keratin 71; Type II; Cytokeratin-71; Keratin 6 Irs; KRT6IRS1; HK6irs1; K6IRS1;

Function

Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle.

Biological Process

Hair follicle morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Intermediate filament organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton

Involvement in disease

Hypotrichosis 13 (HYPT13):
A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT13 is an autosomal dominant form characterized by sparse woolly hair.

Zhang, T., Yao, H., Wang, H., & Sui, T. (2023). Development of Woolly Hair and Hairlessness in a CRISPR− Engineered Mutant Mouse Model with KRT71 Mutations. Cells, 12(13), 1781.

Jacinto, J. G., Markey, A. D., Veiga, I. M., Paris, J. M., Welle, M., Beever, J. E., & Drögemüller, C. (2021). A KRT71 loss-of-function variant results in inner root sheath dysplasia and recessive congenital hypotrichosis of hereford cattle. Genes, 12(7), 1038.

Salmela, E., Niskanen, J., Arumilli, M., Donner, J., Lohi, H., & Hytönen, M. K. (2019). A novel KRT71 variant in curly‐coated dogs. Animal genetics, 50(1), 101-104.

Bauer, A., Hadji Rasouliha, S., Brunner, M. T., Jagannathan, V., Bucher, I., Bannoehr, J., ... & Leeb, T. (2019). A second KRT 71 allele in curly coated dogs. Animal genetics, 50(1), 97-100.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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