Mouse Anti-KRT81 Recombinant Antibody (3B10-5B10) (CBMAB-K2049-LY)

Name: Mouse Anti-KRT81 Recombinant Antibody (3B10-5B10)
SKU: CBMAB-K2049-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3B10-5B10

Application

ELISA, IF, IHC, WB

Immunogen

Full length recombinant corresponding to aa1-202 from human KRTHB1 (AAH21241) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Keratin 81

Introduction

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3887

UniProt ID

Q14533

Alternative Names

Keratin 81; Keratin; Hair; Basic; 1; Metastatic Lymph Node 137 Gene Protein; Type II Hair Keratin Hb1; Type-II Keratin Kb21; Keratin 81; Type II; Hair Keratin K2.9; MLN 137; GhHkb1; KRTHB1; MLN137;

Cellular Location

Cytosol
Extracellular space
Keratin filament

Involvement in disease

Monilethrix (MNLIX):
A disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.

Kang, D. S., Moriarty, A., Wang, Y. J., Thomas, A., Hao, J., Unger, B. A., ... & Yu, M. (2023). Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity. Advanced Science, 2300509.

Park, E., Yoo, J. E., Hwang, H. K., Kang, C. M., Lee, C. K., Kim, M. H., ... & Park, Y. N. (2022). Combined tumor epithelial and stromal histopathology with keratin 81 expression predicts prognosis for pancreatic ductal adenocarcinoma. Journal of Hepato‐Biliary‐Pancreatic Sciences, 29(2), 250-261.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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