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Mouse Anti-KRT81 Recombinant Antibody (3B10-5B10) (CBMAB-K2049-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B10-5B10
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-202 from human KRTHB1 (AAH21241) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 81
Introduction
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3887
UniProt ID
Q14533
Alternative Names
Keratin 81; Keratin; Hair; Basic; 1; Metastatic Lymph Node 137 Gene Protein; Type II Hair Keratin Hb1; Type-II Keratin Kb21; Keratin 81; Type II; Hair Keratin K2.9; MLN 137; GhHkb1; KRTHB1; MLN137;
Cellular Location
Cytosol
Extracellular space
Keratin filament
Involvement in disease
Monilethrix (MNLIX):
A disorder clinically characterized by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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