Sign in or Register   Sign in or Register
  |  

Mouse Anti-L3MBTL1 Recombinant Antibody (CBYJL-1035) (CBMAB-L0447-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to L3Mbtl1 Histone Methyl-Lysine Binding Protein (L3MBTL1). The antibody can be used for immunoassay techniques, such as IP.
See all L3MBTL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1035
Antibody Isotype
IgG
Application
IP

Basic Information

Immunogen
200-530 of 772 of L3MBTL1 Protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 200-530

Target

Full Name
L3Mbtl1 Histone Methyl-Lysine Binding Protein
Introduction
Gene of L3MBTL1 represents a polycomb group gene. L3MBTL1 functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been found. Diseases associated with L3MBTL1 include Shwachman-Diamond Syndrome 1 and Brain Cancer. Among its related pathways are Gene Expression and Regulation of TP53 Activity.
Entrez Gene ID
UniProt ID
Alternative Names
H-L(3)MBT; L3MBTL; ZC2HC3; dJ138B7.3
Function
Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (AC H1bK26me1 and AC H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Biological Process
Chromatin organizationManual Assertion Based On ExperimentIDA:UniProtKB
HemopoiesisManual Assertion Based On ExperimentIEP:UniProtKB
Heterochromatin assemblyManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycle1 PublicationNAS:UniProtKB
Regulation of megakaryocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitotic nuclear divisionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex.
PTM
Ubiquitinated in a VCP/p97-dependent way following DNA damage, leading to its removal from DNA damage sites, promoting accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited to DNA damage sites.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-L3MBTL1 Recombinant Antibody (CBYJL-1035)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare