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Mouse Anti-Lage3 Recombinant Antibody (CBYJL-2407) (CBMAB-L2729-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to L Antigen Family Member 3 (Lage3). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Lage3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBYJL-2407
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
L antigen family member 3
Introduction
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Entrez Gene ID
Mouse66192
Rat293863
UniProt ID
MouseQ9CR70
RatD3ZPW6
Alternative Names
Eso3; Itba2; 1110049G11Rik; EKC/KEOPS complex subunit Lage3; ITBA2 protein homolog
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.
Biological Process
tRNA processingIEA:UniProtKB-KW
tRNA threonylcarbamoyladenosine metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Nucleus
Involvement in disease
Galloway-Mowat syndrome 2, X-linked (GAMOS2):
A form of Galloway-Mowat syndrome, a severe renal-neurological disease characterized by early-onset nephrotic syndrome associated with microcephaly, central nervous system abnormalities, developmental delays, and a propensity for seizures. Brain anomalies include gyration defects ranging from lissencephaly to pachygyria and polymicrogyria, and cerebellar hypoplasia. Most patients show facial dysmorphism characterized by a small, narrow forehead, large/floppy ears, deep-set eyes, hypertelorism and micrognathia. Additional variable features are visual impairment and arachnodactyly. Most patients die in early childhood.

Zhang, H., Jian, J., Chen, H., Zhu, X., Xie, J., & Xu, X. (2023). LAGE3 promotes cell metastasis and stemness in non-small cell lung cancer companied with AKT/PI3K signaling pathway activation. Pathology-Research and Practice, 248, 154700.

Liu, T. L., Lin, S. P., Zenker, M., Chen, T. Y., Chang, J. H., Lin, C. C., & Tsai, J. D. (2023). X-linked recessive Galloway-Mowat syndrome 2 caused by a specific LAGE3 variant. Pediatrics & Neonatology, 64(2), 208-209.

Chen, Y., Yang, Y., Yang, Y., Rao, J., & Bai, H. (2023). Diagnosis delay a family of Galloway-Mowat Syndrome caused by a classical splicing mutation of Lage3. BMC nephrology, 24(1), 1-7.

Li, Y., & Xiong, H. (2022). Correlation of LAGE3 with unfavorable prognosis and promoting tumor development in HCC via PI3K/AKT/mTOR and Ras/RAF/MAPK pathways. BMC cancer, 22(1), 1-13.

Xing, Y., Liu, Y., Qi, Z., Liu, Z., Wang, X., & Zhang, H. (2021). LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway. Cellular & Molecular Biology Letters, 26, 1-16.

Dong, X., Gu, D. N., Wang, O., & Ye, Z. (2020). LAGE3 correlates with tumorigenic immune infiltrates in the clear cell renal cell carcinoma microenvironment. International Immunopharmacology, 87, 106793.

Dong, X., Lv, S., Zhang, X., & Hao, R. (2020). Upregulation of LAGE3 correlates with prognosis and immune infiltrates in colorectal cancer: a bioinformatic analysis. International Immunopharmacology, 85, 106599.

Zhou, Y., Liang, H., Deng, J., Luo, Z., & Long, W. (2020, April). LAGE3 is a potential therapeutic target and prognostic factor in breast cancer: database mining for LAGE family members in human malignancies. In Proceedings of the 2020 5th International Conference on Mathematics and Artificial Intelligence (pp. 18-23).

Long, M., Wang, Y., Chen, D., Wang, Y., Wang, R., Gong, D., ... & Luo, S. (2018). Identification of host cellular proteins LAGE3 and IGFBP6 that interact with orf virus protein ORFV024. Gene, 661, 60-67.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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