Sign in or Register   Sign in or Register
  |  

Mouse Anti-LAMC3 Recombinant Antibody (A859) (CBMAB-AP4224LY)

The product is antibody recognizes LAMC3. The antibody A859 immunoassay techniques such as: ICC, IHC, IP, WB.
See all LAMC3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse
Clone
A859
Antibody Isotype
IgG1, κ
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Gly751~Cys875
Specificity
Mouse
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LAMC3
Entrez Gene ID
23928
UniProt ID
Q9R0B6
Alternative Names
LAM-C3
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Astrocyte developmentIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Visual perceptionIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Involvement in disease
Cortical malformations occipital (OCCM):
A disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.

Falcicchio, G., Riva, A., La Neve, A., Iacomino, M., Lastella, P., Suppressa, P., ... & Striano, P. (2023). Case report: LAMC3-associated cortical malformations: Case report of a novel stop-gain variant and literature review. Frontiers in genetics, 13, 990350.

Abe, K., Ando, K., Kato, M., Saitsu, H., Nakashima, M., Aoki, S., & Kimura, T. (2022). A New Case With Cortical Malformation Caused by Biallelic Variants in LAMC3. Neurology: Genetics, 8(3).

Lei, S. M., Liu, X., Xia, L. P., Ke, Y., Wei, L. W., Li, L., & Yin, F. J. (2021). Relationships between decreased LAMC3 and poor prognosis in ovarian cancer. Zhonghua fu Chan ke za zhi, 56(7), 489-497.

De Angelis, C., Byrne, A. B., Morrow, R., Feng, J., Ha, T., Wang, P., ... & Barnett, C. (2021). Compound heterozygous variants in LAMC3 in association with posterior periventricular nodular heterotopia. BMC Medical Genomics, 14(1), 1-7.

Qian, X., Liu, X., Zhu, Z., Wang, S., Song, X., Chen, G., ... & Cao, L. (2021). Variants in LAMC3 causes occipital cortical malformation. Frontiers in Genetics, 12, 616761.

Kasper, B. S., Kraus, C., Schwarz, M., Rösch, J., Thiel, C. T., Reis, A., & Zweier, C. (2020). A novel splice variant expands the LAMC3‐associated cortical phenotype to frontal only polymicrogyria and adult‐onset epilepsy. American Journal of Medical Genetics Part A, 182(11), 2761-2764.

Urgen, B. M., Topac, Y., Ustun, F. S., Demirayak, P., Oguz, K. K., Kansu, T., ... & Doerschner, K. (2019). Homozygous LAMC3 mutation links to structural and functional changes in visual attention networks. Neuroimage, 190, 242-253.

Zambonin, J. L., Dyment, D. A., Xi, Y., Lamont, R. E., Hartley, T., Miller, E., ... & Venkateswaran, S. (2018). A novel mutation in LAMC3 associated with generalized polymicrogyria of the cortex and epilepsy. neurogenetics, 19, 61-65.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-LAMC3 Recombinant Antibody (A859)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare