Mouse Anti-LAMC3 Recombinant Antibody (A859) (CBMAB-AP4224LY)

Name: Mouse Anti-LAMC3 Recombinant Antibody (A859)
SKU: CBMAB-AP4224LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A859

Application

ICC, IHC, IP, WB

Immunogen

Gly751~Cys875

Specificity

Mouse

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

LAMC3

Entrez Gene ID

23928

UniProt ID

Q9R0B6

Alternative Names

LAM-C3

Function

MAC084Mu22

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Astrocyte developmentIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Visual perceptionIEA:Ensembl

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane

Involvement in disease

Cortical malformations occipital (OCCM):
A disease in which affected individuals develop seizures, sometimes associated with transient visual changes. Brain MRI shows both pachygyria and polymicrogyria restricted to the lateral occipital lobes.

Falcicchio, G., Riva, A., La Neve, A., Iacomino, M., Lastella, P., Suppressa, P., ... & Striano, P. (2023). Case report: LAMC3-associated cortical malformations: Case report of a novel stop-gain variant and literature review. Frontiers in genetics, 13, 990350.

Abe, K., Ando, K., Kato, M., Saitsu, H., Nakashima, M., Aoki, S., & Kimura, T. (2022). A New Case With Cortical Malformation Caused by Biallelic Variants in LAMC3. Neurology: Genetics, 8(3).

Lei, S. M., Liu, X., Xia, L. P., Ke, Y., Wei, L. W., Li, L., & Yin, F. J. (2021). Relationships between decreased LAMC3 and poor prognosis in ovarian cancer. Zhonghua fu Chan ke za zhi, 56(7), 489-497.

De Angelis, C., Byrne, A. B., Morrow, R., Feng, J., Ha, T., Wang, P., ... & Barnett, C. (2021). Compound heterozygous variants in LAMC3 in association with posterior periventricular nodular heterotopia. BMC Medical Genomics, 14(1), 1-7.

Qian, X., Liu, X., Zhu, Z., Wang, S., Song, X., Chen, G., ... & Cao, L. (2021). Variants in LAMC3 causes occipital cortical malformation. Frontiers in Genetics, 12, 616761.

Kasper, B. S., Kraus, C., Schwarz, M., Rösch, J., Thiel, C. T., Reis, A., & Zweier, C. (2020). A novel splice variant expands the LAMC3‐associated cortical phenotype to frontal only polymicrogyria and adult‐onset epilepsy. American Journal of Medical Genetics Part A, 182(11), 2761-2764.

Urgen, B. M., Topac, Y., Ustun, F. S., Demirayak, P., Oguz, K. K., Kansu, T., ... & Doerschner, K. (2019). Homozygous LAMC3 mutation links to structural and functional changes in visual attention networks. Neuroimage, 190, 242-253.

Zambonin, J. L., Dyment, D. A., Xi, Y., Lamont, R. E., Hartley, T., Miller, E., ... & Venkateswaran, S. (2018). A novel mutation in LAMC3 associated with generalized polymicrogyria of the cortex and epilepsy. neurogenetics, 19, 61-65.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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