Mouse Anti-LCK Recombinant Antibody (A875) (CBMAB-AP11393LY)

LCK

LCK,LSK,p56 LCK,p56lck,pp58lck,Protein YT16,Proto oncogene Lck,Tyrosine protein kinase Lck,YT16

E-AB-27231

Activation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
B cell receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Cellular zinc ion homeostasisManual Assertion Based On ExperimentIEP:UniProtKB
Hemopoiesis1 PublicationNAS:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transductionManual Assertion Based On ExperimentIDA:ARUK-UCL
Leukocyte migrationTAS:Reactome
Peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:ARUK-UCL
Platelet activationTAS:Reactome
Positive regulation of heterotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of T cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell receptor signaling pathway1 PublicationNAS:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of lymphocyte activation1 PublicationNAS:UniProtKB
Release of sequestered calcium ion into cytosolISS:UniProtKB
Response to xenobiotic stimulusManual Assertion Based On ExperimentIDA:UniProtKB
T cell costimulationTAS:Reactome
T cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
T cell receptor signaling pathwayTAS:Reactome
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cell membrane
Cytoplasm, cytosol
Present in lipid rafts in an inactive form.

A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.
Immunodeficiency 22 (IMD22):
A primary immunodeficiency characterized by T-cell dysfunction. Affected individuals present with lymphopenia, recurrent infections, severe diarrhea, and failure to thrive.

Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cell receptor signaling.
Myristoylation is required prior to palmitoylation.
Palmitoylation regulates association with the plasma membrane and could be mediated by ZDHHC2.