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Rabbit Anti-LCP1 Recombinant Antibody (CBYJL-1313) (CBMAB-L0894-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Lymphocyte Cytosolic Protein 1 (LCP1). The antibody can be used for immunoassay techniques, such as WB, IHC-P, ICC.
See all LCP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYJL-1313
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Immunogen
A synthetic peptide corresponding to residues in human Plastin L was used as an immunogen.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.05% BSA
Preservative
0.01% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lymphocyte cytosolic protein 1
Introduction
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. Among its related pathways are NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and actin binding.
Entrez Gene ID
Human3936
Mouse18826
Rat306071
UniProt ID
HumanP13796
MouseQ61233
RatQ5XI38
Alternative Names
CP64; HEL-S-37; L-PLASTIN; LC64P; LPL; PLS2
Function
Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397).
Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403).
Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403).
Biological Process
Actin crosslink formationISS:FlyBase
Actin filament bundle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Actin filament network formationManual Assertion Based On ExperimentIBA:GO_Central
Animal organ regenerationIEA:Ensembl
Cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Cortical actin cytoskeleton organizationISS:FlyBase
Extracellular matrix disassemblyManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of podosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein kinase A signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of intracellular protein transportManual Assertion Based On ExperimentIDA:UniProtKB
T cell activation involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Cell junction
Cell projection
Cell projection, ruffle membrane
Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403).
Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079).
Involvement in disease
Chromosomal aberrations involving LCP1 is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;13)(q27;q14), with BCL6.
Defects in LCP1 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.
PTM
Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.

Wang, W. (2022). Pathological Correlation of Lymphocyte Cytosolic Protein 1 in Gastric Cancer and its Effect on Tumor Immune Infiltration. Indian Journal of Pharmaceutical Sciences, 84.

Mahat, U., Garg, B., Yang, C. Y., Mehta, H., Hanna, R., Rogers, H. J., ... & Corey, S. J. (2022). Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood Advances, 6(8), 2581-2594.

Subramani, M., & Yun, J. W. (2021). Loss of lymphocyte cytosolic protein 1 (LCP1) induces browning in 3T3-L1 adipocytes via β3-AR and the ERK-independent signaling pathway. The International Journal of Biochemistry & Cell Biology, 138, 106053.

Mahat, U., Garg, B., Mehta, H. M., Rogers, H. J., Ivanov, A., Yang, C. Y., ... & Corey, S. J. (2021). Lymphocyte Cytosolic Protein 1 I232F Mutation Impairs Granulocytic Proliferation with a G2/M Block in Severe Neutropenia. Blood, 138, 434.

Zeng, Q., Li, L., Feng, Z., Luo, L., Xiong, J., Jie, Z., ... & Li, Z. (2021). LCP1 is a prognostic biomarker correlated with immune infiltrates in gastric cancer. Cancer Biomarkers, 30(1), 105-125.

Shin, E. M., Neja, S. A., Fidan, K., Chua, J. Y. H., Chung, T. H., Bertin, N., ... & Ooi, M. G. M. (2020). Lymphocyte cytosolic protein 1 (LCP1) is a novel TRAF3 dysregulation biomarker with potential prognostic value in multiple myeloma. Genome Instability & Disease, 1, 286-299.

Ge, X., Liu, W., Zhao, W., Feng, S., Duan, A., Ji, C., ... & Cai, W. (2020). Exosomal transfer of LCP1 promotes osteosarcoma cell tumorigenesis and metastasis by activating the JAK2/STAT3 signaling pathway. Molecular Therapy-Nucleic Acids, 21, 900-915.

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For research use only. Not intended for any clinical use.

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