Mouse Anti-LEP Recombinant Antibody (A889) (CBMAB-AP4274LY)

Mouse

Cattle

A889

IgG

ICC, IHC, IP, WB

Asp29~Gln160

Cattle

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

Affinity purity

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

OB, OBS, Obesity Homolog, Obesity Factor, Obese Protein

MAA084Bo21

Activation of protein kinase C activityManual Assertion Based On ExperimentIDA:UniProtKB
Adipose tissue developmentIEA:Ensembl
Adult feeding behaviorISS:HGNC-UCL
AngiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Aorta developmentIEA:Ensembl
Bile acid metabolic processIEA:Ensembl
Bone growthISS:UniProtKB
Bone mineralization involved in bone maturationIEA:Ensembl
Cardiac muscle hypertrophyIEA:Ensembl
Cellular response to insulin stimulusIEA:Ensembl
Cellular response to L-ascorbic acidIEA:Ensembl
Cellular response to leptin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to retinoic acidIEA:Ensembl
Central nervous system neuron developmentIEA:Ensembl
Cholesterol metabolic processIEA:Ensembl
Circadian rhythmIEA:Ensembl
Determination of adult lifespanIEA:Ensembl
Eating behaviorIEA:Ensembl
Elastin metabolic processIEA:Ensembl
Energy reserve metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fatty acid beta-oxidationIEA:Ensembl
Female pregnancyIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Glycerol biosynthetic processIEA:Ensembl
Hormone metabolic processIEA:Ensembl
Insulin secretionIEA:Ensembl
Intestinal absorptionManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionIEA:Ensembl
Leptin-mediated signaling pathwayISS:UniProtKB
Leukocyte tethering or rollingIEA:Ensembl
Lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of appetiteISS:HGNC-UCL
Negative regulation of appetite by leptin-mediated signaling pathwayISS:UniProtKB
Negative regulation of autophagyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cartilage developmentIEA:Ensembl
Negative regulation of glucagon secretionIEA:Ensembl
Negative regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glutamine transportIEA:Ensembl
Negative regulation of lipid storageIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of vasoconstrictionIEA:Ensembl
Ovulation from ovarian follicleIEA:Ensembl
PhagocytosisIEA:Ensembl
Placenta developmentManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of developmental growthManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of fat cell apoptotic processIEA:Ensembl
Positive regulation of follicle-stimulating hormone secretionIEA:Ensembl
Positive regulation of hepatic stellate cell activationIEA:Ensembl
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of interleukin-12 productionIEA:Ensembl
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ion transportIEA:Ensembl
Positive regulation of luteinizing hormone secretionIEA:Ensembl
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peroxisome proliferator activated receptor signaling pathwayIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein import into nucleusIEA:Ensembl
Positive regulation of protein kinase B signalingISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of reactive oxygen species metabolic processIEA:Ensembl
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Prostaglandin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressureIEA:Ensembl
Regulation of bone remodelingISS:UniProtKB
Regulation of brown fat cell differentiationISS:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gluconeogenesisIEA:Ensembl
Regulation of insulin secretionIEA:Ensembl
Regulation of intestinal cholesterol absorptionIEA:Ensembl
Regulation of lipoprotein lipid oxidationIEA:Ensembl
Regulation of natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of steroid biosynthetic processIEA:Ensembl
Response to activityIEA:Ensembl
Response to dietary excessIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to insulinManual Assertion Based On ExperimentIBA:GO_Central
Response to vitamin EIEA:Ensembl
Sexual reproductionManual Assertion Based On ExperimentIMP:UniProtKB
T cell differentiationISS:UniProtKB
Tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIBA:GO_Central

Secreted

Leptin deficiency (LEPD):
A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.