Mouse Anti-LEP Recombinant Antibody (A891) (CBMAB-AP4276LY)

Mouse

Rat

A891

IgG

ICC, IHC, IP, WB

Rat

IgG

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

Affinity purity

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

OB, OBS, Obesity Homolog, Obesity Factor, Obese Protein

MAA084Ra21

Activation of protein kinase C activityManual Assertion Based On ExperimentIDA:UniProtKB
Adipose tissue developmentIEA:Ensembl
Adult feeding behaviorISS:HGNC-UCL
AngiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Aorta developmentIEA:Ensembl
Bile acid metabolic processIEA:Ensembl
Bone growthISS:UniProtKB
Bone mineralization involved in bone maturationIEA:Ensembl
Cardiac muscle hypertrophyIEA:Ensembl
Cellular response to insulin stimulusIEA:Ensembl
Cellular response to L-ascorbic acidIEA:Ensembl
Cellular response to leptin stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to retinoic acidIEA:Ensembl
Central nervous system neuron developmentIEA:Ensembl
Cholesterol metabolic processIEA:Ensembl
Circadian rhythmIEA:Ensembl
Determination of adult lifespanIEA:Ensembl
Eating behaviorIEA:Ensembl
Elastin metabolic processIEA:Ensembl
Energy reserve metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fatty acid beta-oxidationIEA:Ensembl
Female pregnancyIEA:Ensembl
Glucose homeostasisIEA:Ensembl
Glucose metabolic processIEA:Ensembl
Glycerol biosynthetic processIEA:Ensembl
Hormone metabolic processIEA:Ensembl
Insulin secretionIEA:Ensembl
Intestinal absorptionManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular signal transductionIEA:Ensembl
Leptin-mediated signaling pathwayISS:UniProtKB
Leukocyte tethering or rollingIEA:Ensembl
Lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processIEA:Ensembl
Negative regulation of appetiteISS:HGNC-UCL
Negative regulation of appetite by leptin-mediated signaling pathwayISS:UniProtKB
Negative regulation of autophagyManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cartilage developmentIEA:Ensembl
Negative regulation of glucagon secretionIEA:Ensembl
Negative regulation of glucose importManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of glutamine transportIEA:Ensembl
Negative regulation of lipid storageIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Negative regulation of vasoconstrictionIEA:Ensembl
Ovulation from ovarian follicleIEA:Ensembl
PhagocytosisIEA:Ensembl
Placenta developmentManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of developmental growthManual Assertion Based On ExperimentIDA:DFLAT
Positive regulation of fat cell apoptotic processIEA:Ensembl
Positive regulation of follicle-stimulating hormone secretionIEA:Ensembl
Positive regulation of hepatic stellate cell activationIEA:Ensembl
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of interleukin-12 productionIEA:Ensembl
Positive regulation of interleukin-6 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-8 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of ion transportIEA:Ensembl
Positive regulation of luteinizing hormone secretionIEA:Ensembl
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of p38MAPK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of peroxisome proliferator activated receptor signaling pathwayIEA:Ensembl
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein import into nucleusIEA:Ensembl
Positive regulation of protein kinase B signalingISS:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of reactive oxygen species metabolic processIEA:Ensembl
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of TOR signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Prostaglandin secretionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of blood pressureIEA:Ensembl
Regulation of bone remodelingISS:UniProtKB
Regulation of brown fat cell differentiationISS:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cytokine production involved in inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of gluconeogenesisIEA:Ensembl
Regulation of insulin secretionIEA:Ensembl
Regulation of intestinal cholesterol absorptionIEA:Ensembl
Regulation of lipoprotein lipid oxidationIEA:Ensembl
Regulation of natural killer cell activationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of steroid biosynthetic processIEA:Ensembl
Response to activityIEA:Ensembl
Response to dietary excessIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to ethanolIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to insulinManual Assertion Based On ExperimentIBA:GO_Central
Response to vitamin EIEA:Ensembl
Sexual reproductionManual Assertion Based On ExperimentIMP:UniProtKB
T cell differentiationISS:UniProtKB
Tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIBA:GO_Central

Secreted

Leptin deficiency (LEPD):
A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age.