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Mouse Anti-LGALS3BP Recombinant Antibody (SP-2) (CBMAB-2144CQ)

This product is a mouse monoclonal antibody that recognizes LGALS3BP. The antibody SP-2 can be used for immunoassay techniques such as: IHC, WB.
See all LGALS3BP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
SP-2
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LGALS3BP
Introduction
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. Diseases associated with LGALS3BP include Ostertagiasis and Trichostrongyloidiasis. Among its related pathways are Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is BTBD17.
Entrez Gene ID
3959
UniProt ID
Q08380
Alternative Names
90K; CyCAP; Ppicap; MAC-2BP; Tango10b; galectin-3-binding protein; cyp-C-associated protein; mama; peptidylprolyl isomerase C-associated protein; EC 3.6.1.6; M2BP; gp90; CyCAP; BTBD17B; MAC-2-BP; TANGO10B; galectin-3-binding protein; L3 antigen; MAC2BP; Mac-2-binding protein; basement membrane autoantigen p105; lectin galactoside-binding soluble 3-binding protein; mac-2 BP; serum protein 90K; transport and golgi organization 10 homolog B; tumor-associated antigen 90K; EC 3.6.1.6
Function
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Secreted, extracellular space, extracellular matrix

Zhao, C., Liu, Y., Meng, J., Wang, X., Liu, X., Li, W., ... & Hou, S. (2022). Lgals3bp in Microglia Promotes Retinal Angiogenesis through Pi3k/Akt Pathway During Hypoxia. Investigative Ophthalmology & Visual Science, 63(8), 25-25.

Song, Y., Wang, M., Tong, H., Tan, Y., Hu, X., Wang, K., & Wan, X. (2021). Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression. Oncogene, 40(3), 633-646.

Kyrousi, C., O’neill, A. C., Brazovskaja, A., He, Z., Kielkowski, P., Coquand, L., ... & Cappello, S. (2021). Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity. Nature Communications, 12(1), 6298.

Luo, M., Zhang, Q., Hu, Y., Sun, C., Sheng, Y., & Deng, C. (2021). Lgals3bp: A potential plasma biomarker associated with diagnosis and prognosis in patients with sepsis. Infection and Drug Resistance, 2863-2871.

Cho, S. H., Shim, H. J., Park, M. R., Choi, J. N., Akanda, M. R., Hwang, J. E., ... & Chung, I. J. (2021). Lgals3bp suppresses colon inflammation and tumorigenesis through the downregulation of TAK1-NF-κB signaling. Cell death discovery, 7(1), 65.

Costa, J., Pronto-Laborinho, A., Pinto, S., Gromicho, M., Bonucci, S., Tranfield, E., ... & de Carvalho, M. (2020). Investigating LGALS3BP/90 K glycoprotein in the cerebrospinal fluid of patients with neurological diseases. Scientific reports, 10(1), 5649.

Kimura, R., Yoshimaru, T., Matsushita, Y., Matsuo, T., Ono, M., Park, J. H., ... & Katagiri, T. (2020). The GALNT6‑LGALS3BP axis promotes breast cancer cell growth. International Journal of Oncology, 56(2), 581-595.

Zhang, X., Ding, H., Lu, Z., Ding, L., Song, Y., Jing, Y., ... & Ni, Y. (2019). Increased LGALS3BP promotes proliferation and migration of oral squamous cell carcinoma via PI3K/AKT pathway. Cellular Signalling, 63, 109359.

Xu, G., Xia, Z., Deng, F., Liu, L., Wang, Q., Yu, Y., ... & Liu, S. (2019). Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS pathogens, 15(8), e1008002.

Lodermeyer, V., Ssebyatika, G., Passos, V., Ponnurangam, A., Malassa, A., Ewald, E., ... & Goffinet, C. (2018). The antiviral activity of the cellular glycoprotein LGALS3BP/90K is species specific. Journal of virology, 92(14), 10-1128.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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