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Mouse Anti-LGALS4 Recombinant Antibody (CBLG1-312) (CBMAB-G1122-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-312
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lectin, galactoside-binding, soluble, 4
Introduction
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal cancer.
Entrez Gene ID
3960
UniProt ID
P56470
Alternative Names
GAL4; L36LBP
Function
Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Collagen-containing extracellular matrix
Cytosol
Extracellular space
Plasma membrane
More Infomation

Cheraghi-Shavi, T., Jalal, R., & Minuchehr, Z. (2023). TGM2, HMGA2, FXYD3, and LGALS4 genes as biomarkers in acquired oxaliplatin resistance of human colorectal cancer: A systems biology approach. Plos one, 18(8), e0289535.

Ferlizza, E., Solmi, R., Mattei, G., Miglio, R., Nardi, E., Sgarzi, M., ... & Lauriola, M. (2021). CEA Cell Adhesion Molecule 6 (CEACAM6), Collagen Type I Alpha 2 Chain (COL1A2), Galectin 4 (LGALS4) and Tetraspanin 8 (TSPAN8) mRNAs as blood biomarkers for colorectal cancer. Italian Journal of Anatomy & Embryology/Archivio Italiano di Anatomia Ed Embriologia, 125.

Acharjee, A., Agarwal, P., Nash, K., Bano, S., Rahman, T., & Gkoutos, G. V. (2021). Immune infiltration and prognostic and diagnostic use of LGALS4 in colon adenocarcinoma and bladder urothelial carcinoma. American journal of translational research, 13(10), 11353.

Ferlizza, E., Solmi, R., Miglio, R., Nardi, E., Mattei, G., Sgarzi, M., & Lauriola, M. (2020). Colorectal cancer screening: Assessment of CEACAM6, LGALS4, TSPAN8 and COL1A2 as blood markers in faecal immunochemical test negative subjects. Journal of Advanced Research, 24, 99-107.

Ding, Y., Cao, Q., Wang, C., Duan, H., & Shen, H. (2019). LGALS4 as a prognostic factor in urothelial carcinoma of bladder affects cell functions. Technology in Cancer Research & Treatment, 18, 1533033819876601.

Rodia, M. T., Solmi, R., Pasini, F., Nardi, E., Mattei, G., Ugolini, G., ... & Lauriola, M. (2018). LGALS4, CEACAM6, TSPAN8, and COL1A2: Blood markers for colorectal cancer—validation in a cohort of subjects with positive fecal immunochemical test result. Clinical Colorectal Cancer, 17(2), e217-e228.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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