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Rat Anti-LGI4 Recombinant Antibody (CBYCL-278) (CBMAB-L0179-YC)

Provided herein is a Rat monoclonal antibody against Mouse LGI4. The antibody can be used for immunoassay techniques, such as IF, IHC, WB.
See all LGI4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYCL-278
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 0.1% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LGI4
Introduction
LGI4 (Leucine Rich Repeat LGI Family Member 4) is a protein coding gene. Diseases associated with LGI4 include Arthrogryposis Multiplex Congenita, Neurogenic, With Myelin Defectand Epilepsy, Familial Temporal Lobe, 1. Among its related pathways are Developmental Biology and LGI-ADAM interactions.
Entrez Gene ID
163175
UniProt ID
Q8N135
Alternative Names
LGIL3; Leucine rich glioma inactivated gene 4; Leucine rich glioma inactivated protein 4; leucine-rich repeat LGI family member 4; Leucine rich repeat LGI family member 4; LGI1 like protein 3; LGI4; Lgi4 protein; Lgil3; LGI4_HUMAN
Function
Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).
Biological Process
Adult locomotory behaviorIEA:Ensembl
Glial cell proliferationIEA:Ensembl
Myelination in peripheral nervous systemManual Assertion Based On ExperimentIBA:GO_Central
Neuron maturationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted
Involvement in disease
Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect (AMC1):
A form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMC1 is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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