Rat Anti-LGI4 Recombinant Antibody (CBYCL-278) (CBMAB-L0179-YC)

Name: Rat Anti-LGI4 Recombinant Antibody (CBYCL-278)
SKU: CBMAB-L0179-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYCL-278

Application

IF, IHC, WB

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4, with 0.1% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LGI4

Introduction

LGI4 (Leucine Rich Repeat LGI Family Member 4) is a protein coding gene. Diseases associated with LGI4 include Arthrogryposis Multiplex Congenita, Neurogenic, With Myelin Defectand Epilepsy, Familial Temporal Lobe, 1. Among its related pathways are Developmental Biology and LGI-ADAM interactions.

Entrez Gene ID

163175

UniProt ID

Q8N135

Alternative Names

LGIL3; Leucine rich glioma inactivated gene 4; Leucine rich glioma inactivated protein 4; leucine-rich repeat LGI family member 4; Leucine rich repeat LGI family member 4; LGI1 like protein 3; LGI4; Lgi4 protein; Lgil3; LGI4_HUMAN

Function

Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).

Biological Process

Adult locomotory behaviorIEA:Ensembl
Glial cell proliferationIEA:Ensembl
Myelination in peripheral nervous systemManual Assertion Based On ExperimentIBA:GO_Central
Neuron maturationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of myelinationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Secreted

Involvement in disease

Arthrogryposis multiplex congenita 1, neurogenic, with myelin defect (AMC1):
A form of arthrogryposis multiplex congenita, a developmental condition characterized by multiple joint contractures resulting from reduced or absent fetal movements. AMC1 is an autosomal recessive severe form with onset in utero. Most affected individuals die in utero. Those who survive have generalized contractures and hypotonia. The disorder is caused by a neurogenic defect and poor or absent myelin formation around peripheral nerves rather than by a muscular defect.

Zhang, X., Kira, J. I., Ogata, H., Imamura, T., Mitsuishi, M., Fujii, T., ... & Nakamura, Y. (2023). Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy. Neurology-Neuroimmunology Neuroinflammation, 10(2).

Mishra, S., Rai, A., Srivastava, P., & Phadke, S. R. (2020). A mild phenotype of LGI4-related arthrogryposis multiplex congenita with intrafamilial variability. European Journal of Medical Genetics, 63(3), 103756.

Gupta, G., Kumar, N., & Chandra, R. (2018). ASSOCIATION ANALYSIS OF [gamma] 2 SUBUNIT OF [gamma]-AMINOBUTYRIC ACID TYPE-A RECEPTOR (GABRG2) AND LEUCINE-RICH GLIOMA-INACTIVATED 4 GENE (LGI-4) POLYMORPHISMS WITH IDIOPATHIC EPILEPSIES AND FEBRILE SEIZURES. Journal of Evolution of Medical and Dental Sciences, 7(39), 5082-5086.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rat Anti-LGI4 Recombinant Antibody (KT18) (CAT#: CBMAB-AO701LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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