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Mouse Anti-LIF Recombinant Antibody (CBFYH-3606) (CBMAB-H4162-FY)

This product is mouse antibody that recognizes LIF. The antibody CBFYH-3606 can be used for immunoassay techniques such as: FC, IP.
See all LIF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-3606
Antibody Isotype
IgG1
Application
FC, IP

Basic Information

Immunogen
Gp190-Fc fusion protein Hito
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukemia Inhibitory Factor
Introduction
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems.
Entrez Gene ID
UniProt ID
Alternative Names
CDF; DIA; HILDA; MLPLI
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
Biological Process
Blood vessel remodelingIEA:Ensembl
DecidualizationIEA:Ensembl
Embryo implantationIEA:Ensembl
Immune responseIEA:InterPro
Leukemia inhibitory factor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Lung alveolus developmentIEA:Ensembl
Lung lobe morphogenesisIEA:Ensembl
Lung vasculature developmentIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Muscle organ morphogenesisIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Negative regulation of ERK1 and ERK2 cascadeIEA:Ensembl
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Negative regulation of meiotic nuclear divisionIEA:Ensembl
Neuron developmentIEA:Ensembl
Positive regulation of astrocyte differentiationIEA:Ensembl
Positive regulation of cell adhesion mediated by integrinManual Assertion Based On ExperimentIMP:CACAO
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of histone H3-K27 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of macrophage differentiationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of protein localization to nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of metanephric nephron tubule epithelial cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIEA:Ensembl
Spongiotrophoblast differentiationIEA:Ensembl
Stem cell differentiationIEA:Ensembl
Stem cell population maintenanceIEA:Ensembl
Trophoblast giant cell differentiationIEA:Ensembl
Tyrosine phosphorylation of STAT proteinIEA:Ensembl
Cellular Location
Secreted

Feng, Y., Ye, D., Wang, Z., Pan, H., Lu, X., Wang, M., ... & Wan, J. (2022). The role of interleukin-6 family members in cardiovascular diseases. Frontiers in cardiovascular medicine, 9, 818890.

Abaurrea, A., Araujo, A. M., & Caffarel, M. M. (2021). The role of the il-6 cytokine family in epithelial–mesenchymal plasticity in cancer progression. International journal of molecular sciences, 22(15), 8334.

van Duijneveldt, G., Griffin, M. D., & Putoczki, T. L. (2020). Emerging roles for the IL-6 family of cytokines in pancreatic cancer. Clinical Science, 134(16), 2091-2115.

Kang, S., Narazaki, M., Metwally, H., & Kishimoto, T. (2020). Historical overview of the interleukin-6 family cytokine. Journal of Experimental Medicine, 217(5).

Murakami, M., Kamimura, D., & Hirano, T. (2019). Pleiotropy and specificity: insights from the interleukin 6 family of cytokines. Immunity, 50(4), 812-831.

Lokau, J., Schoeder, V., Haybaeck, J., & Garbers, C. (2019). Jak-stat signaling induced by interleukin-6 family cytokines in hepatocellular carcinoma. Cancers, 11(11), 1704.

Rasmussen, J. M., Graham, A. M., Entringer, S., Gilmore, J. H., Styner, M., Fair, D. A., ... & Buss, C. (2019). Maternal Interleukin-6 concentration during pregnancy is associated with variation in frontolimbic white matter and cognitive development in early life. Neuroimage, 185, 825-835.

Jones, S. A., & Jenkins, B. J. (2018). Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature reviews immunology, 18(12), 773-789.

Rose-John, S. (2018). Interleukin-6 family cytokines. Cold Spring Harbor perspectives in biology, 10(2), a028415.

Unver, N., & McAllister, F. (2018). IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets. Cytokine & growth factor reviews, 41, 10-17.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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