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Mouse Anti-LIMD2 Recombinant Antibody (CBYJL-1709) (CBMAB-L1590-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lim Domain Containing 2 (LIMD2). The antibody can be used for immunoassay techniques, such as WB, IF, IHC.
See all LIMD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1709
Antibody Isotype
IgG
Application
WB, IF, IHC

Basic Information

Immunogen
Recombinant LIMD2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LIM domain containing 2
Introduction
LIMD2 acts as an activator of the protein-kinase ILK, thereby regulating cell motility.
Entrez Gene ID
80774
UniProt ID
Q9BT23
Alternative Names
SB143
Function
Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).

Hu, H., Wang, Y., Dong, Y., Wang, L., Chen, Y., Zhou, Y., & Sun, L. (2023). Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway. Molecular Biology Reports, 50(11), 8985-8993.

Zhong, Q. Y., Ying-Wei, X. I. E., Zhi-Liang, C. H. E. N., Yu-Qing, C. H. E. N., Yue-Xin, L. I. U., Wen-Lian, X. I. E., & Wei, Y. A. N. (2022). LIMD2 promotes tumor proliferation, invasion, and epithelial-mesenchymal transition in clear cell renal cell carcinoma. Neoplasma, 69(4).

Chen, L., Qian, J., You, Q., & Ma, J. (2021). LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway. Bioengineered, 12(2), 10089-10100.

Chen, Y., Huang, X., Zhu, K., Li, C., Peng, H., Chen, L., ... & Xu, Y. (2021). LIMD2 is a prognostic and predictive marker in patients with esophageal cancer based on a cerna network analysis. Frontiers in Genetics, 12, 774432.

Araldi, R. P., de Melo, T. C., Levy, D., de Souza, D. M., Maurício, B., Colozza-Gama, G. A., ... & Cerutti, J. M. (2020). LIMD2 regulates key steps of metastasis cascade in papillary thyroid cancer cells via MAPK crosstalk. Cells, 9(11), 2522.

Zhang, F., Qin, S., Xiao, X., Tan, Y., Hao, P., & Xu, Y. (2019). Overexpression of LIMD2 promotes the progression of non‑small cell lung cancer. Oncology letters, 18(2), 2073-2081.

Pinheiro dos Santos, M. J. C., Bastos, A. U., da Costa, V. R., Delcelo, R., Lindsey, S. C., Colozza-Gama, G. A., ... & Cerutti, J. M. (2018). LIMD2 is overexpressed in BRAF V600E-positive papillary thyroid carcinomas and matched lymph node metastases. Endocrine Pathology, 29, 222-230.

Wang, F., Li, Z., Xu, L., Li, Y., Li, Y., Zhang, X., ... & Liu, D. (2018). LIMD2 targeted by miR‑34a promotes the proliferation and invasion of non‑small cell lung cancer cells. Molecular medicine reports, 18(5), 4760-4766.

Dedhar, S., & Awrey, S. (2018). LIMD2 is an intracellular activator of Integrin Linked Kinase (ILK) activity and GSK‐3/Akt/beta‐catenin signaling. The FASEB Journal, 32, 666-1.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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