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Mouse Anti-LINGO2 Recombinant Antibody (CBYJL-1763) (CBMAB-L1673-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat And Ig Domain Containing 2 (LINGO2). The antibody can be used for immunoassay techniques, such as FC.
See all LINGO2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1763
Antibody Isotype
IgG2a
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leucine Rich Repeat And Ig Domain Containing 2
Introduction
Diseases associated with LINGO2 include Essential Tremor. An important paralog of this gene is LINGO1.
Entrez Gene ID
UniProt ID
Alternative Names
LERN3; LRRN6C
Biological Process
Positive regulation of synapse assemblyIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 28-545
Helical: 546-566
Cytoplasmic: 567-606

Li, D., Lian, L., Huang, L., Gamdzyk, M., Huang, Y., Doycheva, D., ... & Zhang, J. H. (2024). Delayed recanalization reduced neuronal apoptosis and neurological deficits by enhancing liver-derived trefoil factor 3-mediated neuroprotection via LINGO2/EGFR/Src signaling pathway after middle cerebral artery occlusion in rats. Experimental Neurology, 371, 114607.

Dudem, S., Boon, P. X., Mullins, N., McClafferty, H., Shipston, M. J., Wilkinson, R. D., ... & Hollywood, M. A. (2023). Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels. Journal of Biological Chemistry, 299(3).

Tomita, T., Yoshida, F., Nagatomo, R., Kimura, M., Shun, S., Nao, Y., ... & Lichtenthaler, S. (2023). Soluble form of Lingo2, an autism spectrum disorder-associated molecule, functions as an excitatory synapse organizer in neurons.

Chang, W. M., Li, L. J., Lin, C. H., Hsiao, M., & Chang, P. M. H. (2023). Abstract LB270: LINGO2-microRNA cluster controls oral cancer stemness ability and cancer progression. Cancer Research, 83(8_Supplement), LB270-LB270.

Soraya, G. V., Ulhaq, Z. S., & Garcia, C. P. (2021). Implication of the LINGO2 gene in the predisposition to movement disorders. Brain Science Advances, 7(4), 257-262.

Soraya, G. V., Ulhaq, Z. S., & Garcia, C. P. (2020). LINGO2 and movement disorder predisposition: Results of a meta-analysis. Available at SSRN 3691470.

Belle, N. M., Ji, Y., Herbine, K., Wei, Y., Park, J., Zullo, K., ... & Herbert, D. B. R. (2019). TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths. Nature communications, 10(1), 4408.

Jo, J. H., Park, S. B., Park, S., Lee, H. S., Kim, C., Jung, D. E., & Song, S. Y. (2019). Novel gastric cancer stem cell-related marker LINGO2 is associated with cancer cell phenotype and patient outcome. International journal of molecular sciences, 20(3), 555.

Su, T., Ren, Q., Lu, Y., Tai, W., Zhu, Y., Li, Z., ... & Ma, J. (2019). A genetic variant in LINGO2 contributes to the risk of gestational diabetes mellitus in a Chinese population. Journal of Cellular Physiology, 234(5), 7012-7018.

Ji, Y., Wei, Y., Park, J., Hung, L. Y., Young, T., Herbine, K., ... & Herbert, D. B. R. (2018). TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection. BioRxiv, 469700.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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