Mouse Anti-LLGL2 Recombinant Antibody (CBYCL-361) (CBMAB-L0262-YC)

Name: Mouse Anti-LLGL2 Recombinant Antibody (CBYCL-361)
SKU: CBMAB-L0262-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-361

Application

WB, IHC-P, FC

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LLGL2

Introduction

LLGL2 (LLGL2, Scribble Cell Polarity Complex Component) is a protein coding gene. Diseases associated with LLGL2 include Pontocerebellar Hypoplasia, Type 2A andPontoneocerebellar Hypoplasia. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Actin Nucleation by ARP-WASP Complex.

Entrez Gene ID

3993

UniProt ID

Q6P1M3

Alternative Names

LGL2; HGL; Hugl-2

Function

Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.

Biological Process

Cell divisionIEA:UniProtKB-KW
Cortical actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Establishment of spindle orientationManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity1 PublicationIC:ComplexPortal
ExocytosisIEA:UniProtKB-KW
Leucine transportManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of establishment or maintenance of cell polarityManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of Notch signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Regulation of protein secretionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.

PTM

Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex.

Gu, Q. Y., Liu, Y. X., Wang, J. L., Huang, X. L., Li, R. N., & Linghu, H. (2023). LLGL2 Inhibits Ovarian Cancer Metastasis by Regulating Cytoskeleton Remodeling via ACTN1. Cancers, 15(24), 5880.

Bii, V. M., Rudoy, D., Klezovitch, O., & Vasioukhin, V. (2023). Lethal giant larvae gene family (Llgl1 and Llgl2) functions as a tumor suppressor in mouse skin epidermis. bioRxiv, 2023-03.

Zhang, W., Wang, M., Liu, L. T., Cui, D., Liu, M., & Liu, D. G. (2023). Differential expression of LLGL2 in prostate ductal adenocarcinoma and acinar adenocarcinoma and its significance. Zhonghua Bing li xue za zhi= Chinese Journal of Pathology, 52(10), 1012-1016.

Zhang, S., Chen, Y., Hu, Q., Zhao, T., Wang, Z., Zhou, Y., ... & Liu, K. (2022). SOX2 inhibits LLGL2 polarity protein in esophageal squamous cell carcinoma via miRNA-142-3p. Cancer Biology & Therapy, 23(1), 1-15.

Hisada, T., Kondo, N., Wanifuchi-Endo, Y., Osaga, S., Fujita, T., Asano, T., ... & Toyama, T. (2022). Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer. Scientific Reports, 12(1), 16515.

Kim, K. H., Hong, G. L., Kim, Y. J., Lee, H. J., & Jung, J. Y. (2022). Silencing of LLGL2 Suppresses the Estradiol-Induced BPH-1 Cell Proliferation through the Regulation of Autophagy. Biomedicines, 10(8), 1981.

Leng, S., Xie, F., Liu, J., Shen, J., Quan, G., & Wen, T. (2021). LLGL2 Increases Ca2+ influx and exerts oncogenic activities via PI3K/AKT signaling pathway in hepatocellular carcinoma. Frontiers in Oncology, 11, 683629.

Hisada, T., Kondo, N., Endo, Y., Asano, T., Uemoto, Y., Nishikawa, S., ... & Toyama, T. (2020). Abstract P6-04-11: LLGL2 is involved in resistance to tamoxifen in estrogen receptor-alpha positive breast cancer patients. Cancer Research, 80(4_Supplement), P6-04.

Saito, Y., Li, L., Coyaud, E., Luna, A., Sander, C., Raught, B., ... & Muthuswamy, S. K. (2019). LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature, 569(7755), 275-279.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

LLGL2 Matched Antibody Pair (698) (CAT#: APMAB-698LY)

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LLGL2 Matched Antibody Pair (698) (CAT#: APMAB-698LY)

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Isotype control

For research use only. Not intended for any clinical use.

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