Mouse Anti-LMBR1 Recombinant Antibody (CBYCL-368) (CBMAB-L0269-YC)

Name: Mouse Anti-LMBR1 Recombinant Antibody (CBYCL-368)
SKU: CBMAB-L0269-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCL-368

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 214-296

More Infomation

Target

Full Name

limb region 1 homolog (mouse)

Introduction

LMBR1 is a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression.

Entrez Gene ID

64327

UniProt ID

Q8WVP7

Alternative Names

ACHP; C7orf2; DIF14; LSS; PPD2; THYP; TPT; ZRS

Function

Putative membrane receptor.

Biological Process

Embryonic digit morphogenesisIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Involvement in disease

Preaxial polydactyly 2 (PPD2):
Polydactyly consists of duplication of the distal phalanx. The thumb in PPD2 is usually opposable and possesses a normal metacarpal.
Acheiropody (ACHP):
Very rare condition characterized by bilateral congenital amputations of the hands and feet. The specific malformative phenotype consists of a complete amputation of the distal epiphysis of the humerus, amputation of the tibial diaphysis and aplasia of the radius, ulna, fibula and of all the bones of the hands and feet.
Syndactyly 4 (SDTY4):
A form of syndactyly, a congenital anomaly of the hand or foot marked by persistence of the webbing between adjacent digits that are more or less completely attached. SDTY4 is characterized by complete bilateral syndactyly (involving all digits 1 to 5). A frequent association with polydactyly (with six metacarpals and six digits) has been reported. Feet are affected occasionally.
Hypoplasia or aplasia of tibia with polydactyly (THYP):
An autosomal dominant disease characterized by hypoplastic or absent tibia, and polydactyly.
Laurin-Sandrow syndrome (LSS):
A rare autosomal dominant disorder characterized by polysyndactyly of hands and/or feet, mirror image duplication of the feet, nasal defects, and loss of identity between fibula and tibia. Some patients do not have nasal abnormalities (segmental Laurin-Sandrow syndrome).

Topology

Extracellular: 1-19
Helical: 20-40
Cytoplasmic: 41-62
Helical: 63-83
Extracellular: 84-110
Helical: 111-131
Cytoplasmic: 132-151
Helical: 152-172
Extracellular: 173-187
Helical: 188-208
Cytoplasmic: 209-291
Helical: 292-312
Extracellular: 313-339
Helical: 340-360
Cytoplasmic: 361-383
Helical: 384-404
Extracellular: 405-426
Helical: 427-447
Cytoplasmic: 448-490

Yan, C., Li, N., Xiao, T., Ye, X., Fu, L., Ye, Y., ... & Yu, J. (2022). Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis. Journal of Translational Medicine, 20(1), 208.

Xu, J., Wu, J., Teng, X., Cai, L., Yuan, H., Chen, X., ... & Chen, H. (2020). Large duplication in LMBR1 gene in a large Chinese pedigree with triphalangeal thumb polysyndactyly syndrome. American Journal of Medical Genetics Part A, 182(9), 2117-2123.

Shi, L., Huang, H., Jiang, Q., Huang, R., Fu, W., Mao, L., ... & Wu, J. (2020). Sub-exome target sequencing in a family with syndactyly type IV due to a novel partial duplication of the LMBR1 gene: first case report in Fujian Province of China. Frontiers in Genetics, 11, 130.

Shi, L., Huang, H., Jiang, Q., Huang, R., Fu, W., Mao, L., ... & Wu, J. (2018). A familial case of Syndactyly type IV due to a novel duplication of~ 222.23 kb covering exons 2-17 of the LMBR1 gene: a case report. bioRxiv, 420588.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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