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Mouse Anti-LMO7 Recombinant Antibody (4B4) (CBMAB-L1887-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lim Domain 7 (LMO7). The antibody can be used for immunoassay techniques, such as ELISA, IF.
See all LMO7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B4
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa 453-540 from human LMO7 (NP_005349) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 453-540

Target

Full Name
LIM domain 7
Introduction
LMO7 is a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be associated with protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of some variants is not known.
Entrez Gene ID
4008
UniProt ID
Q8WWI1
Alternative Names
LOMP; FBX20; LMO7b; FBXO20
Biological Process
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Protein ubiquitination1 PublicationNAS:UniProtKB
Regulation of cell adhesionIEA:InterPro
Regulation of signalingIEA:InterPro
Cellular Location
Apical plasma membrane
Cell surface
Cytoplasm
Cytosol
Focal adhesion
Nuclear envelope
Nucleus
Ubiquitin ligase complex

Wu, T., Chen, X., Xu, K., Dai, C., Li, X., Li, J., ... & Yuan, Y. (2024). LIM domain only 7 negatively controls nonalcoholic steatohepatitis in the setting of hyperlipidemia. Hepatology, 79(1), 149-166.

Matsuda, M., Chu, C. W., & Sokol, S. Y. (2022). Lmo7 recruits myosin II heavy chain to regulate actomyosin contractility and apical domain size in Xenopus ectoderm. Development, 149(10), dev200236.

Gomes, G., do Amaral, M. J., Bagri, K. M., Vasconcellos, L. M., Almeida, M. D. S., Alvares, L. E., & Mermelstein, C. (2021). New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells. International Journal of Molecular Sciences, 22(23), 12885.

Matsuda, M., Chu, C. W., & Sokol, S. Y. (2021). LMO7-dependent apical constriction requires the binding of the Myosin heavy chain. bioRxiv, 2021-05.

Guérin, A., Roy, N. H., Kugler, E. M., Berry, L., Burkhardt, J. K., Shin, J. B., & Striepen, B. (2021). Cryptosporidium rhoptry effector protein ROP1 injected during invasion targets the host cytoskeletal modulator LMO7. Cell Host & Microbe, 29(9), 1407-1420.

Xie, Y., Ostriker, A. C., Jin, Y., Hu, H., Sizer, A. J., Peng, G., ... & Martin, K. A. (2019). LMO7 is a negative feedback regulator of transforming growth factor β signaling and fibrosis. Circulation, 139(5), 679-693.

Tzeng, Y. W., Li, D. Y., Chen, Y., Yang, C. H., Chang, C. Y., & Juang, Y. L. (2018). LMO7 exerts an effect on mitosis progression and the spindle assembly checkpoint. The International Journal of Biochemistry & Cell Biology, 94, 22-30.

Karlsson, T., Kvarnbrink, S., Holmlund, C., Botling, J., Micke, P., Henriksson, R., ... & Hedman, H. (2018). LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease. Lung cancer, 125, 174-184.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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