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Rabbit Anti-LNPEP Recombinant Antibody (SP15) (CBMAB-L1901-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Leucyl And Cystinyl Aminopeptidase (LNPEP). The antibody can be used for immunoassay techniques, such as IHC-P, IHC-Fr.
See all LNPEP antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
SP15
Antibody Isotype
IgG
Application
IHC-P, IHC-Fr

Basic Information

Immunogen
Recombinant protein encoding human Placental Alkaline Phosphatase (PLAP).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
leucyl and cystinyl aminopeptidase
Introduction
LNPEP a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
Human4012
Mouse240028
Rat171105
UniProt ID
HumanQ9UIQ6
MouseQ8C129
RatP97629
Alternative Names
CAP; IRAP; PLAP; P-LAP
Function
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain.
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentTAS:Reactome
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Female pregnancyManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Peptide catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Protein catabolic processIEA:Ensembl
Protein polyubiquitinationTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central
Regulation of blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionIEA:Ensembl
Cellular Location
Cell membrane
In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.
Leucyl-cystinyl aminopeptidase, pregnancy serum form
Secreted
During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Topology
Cytoplasmic: 1-110
Helical: 111-131
Extracellular: 132-1025
PTM
The pregnancy serum form is derived from the membrane-bound form by proteolytic processing.
N-glycosylated.

Marusina, A. I., Ji-Xu, A., Le, S. T., Toussi, A., Tsoi, L. C., Li, Q., ... & Maverakis, E. (2023). Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis. Journal of Investigative Dermatology.

Wilczyński, K. M., Auguściak-Duma, A., Stasik, A., Cichoń, L., Kawalec, A., & Janas-Kozik, M. (2023). Association of OXTR, AVPR1a, LNPEP, and CD38 Genes’ Expression with the Clinical Presentation of Autism Spectrum Disorder. Current Issues in Molecular Biology, 45(10), 8359-8371.

Ma, Q., Che, L., Wang, W., Li, G., Zhang, Y., Chen, Y., ... & Chang, L. (2022). LNPEP as a Prognostic-Related Biomarker in Ovarian Cancer Correlating with Immune Infiltrates.

Ouyang, X., Yao, L., Liu, G., Liu, S., Gong, L., & Xiao, Y. (2021). Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532–3p/RAB9A signal under hypoxia. Biochemical and Biophysical Research Communications, 557, 26-32.

Paladini, F., Fiorillo, M. T., Tedeschi, V., Mattorre, B., & Sorrentino, R. (2020). The multifaceted nature of aminopeptidases ERAP1, ERAP2, and LNPEP: from evolution to disease. Frontiers in immunology, 11, 1576.

Khaliq, O. P., Konoshita, T., Moodley, J., & Naicker, T. (2020). The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 252, 160-165.

Abimbola, J. K., Edwards, J. M., & Lema, S. C. (2020). Expression profiles of genes encoding arginine vasotocin and isotocin receptors and the leucyl-cystinyl aminopeptidase (LNPEP) nonapeptide degradation enzyme in blue tilapia (Oreochromis aureus) during high salinity acclimation. Marine and Freshwater Behaviour and Physiology, 53(4), 163-191.

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For research use only. Not intended for any clinical use.

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