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Mouse Anti-LNX1 Recombinant Antibody (1H9) (CBMAB-L1902-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Ligand Of Numb-Protein X 1 (LNX1). The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all LNX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H9
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Immunogen
Human LNX1/LNX.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ligand of numb-protein X 1
Introduction
Ligand of numb-protein X 1 is a membrane-bound protein that functions in signal transduction and protein interactions. Ligand of numb-protein X 1 is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been found. A pseudogene, which is located on chromosome 17, has been identified for this gene.
Entrez Gene ID
84708
UniProt ID
Q8TBB1
Alternative Names
LNX; MPDZ; PDZRN2
Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65.
Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.
Biological Process
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm

Canesin, G., Feldbrügge, L., Wei, G., Janovicova, L., Janikova, M., Csizmadia, E., ... & Wegiel, B. (2022). Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. Iscience, 25(9).

Zhang, T., Wang, C., Wei, J., Zhu, Z., Wang, X., & Sun, C. (2022). Ligand-of-Numb protein X1 controls the coxsackievirus B3-induced myocarditis via regulating the stability of coxsackievirus and adenovirus receptor. Genes & Immunity, 23(1), 42-46.

Li, N., Chen, S., Xu, N. J., Sun, S., Chen, J. J., & Liu, X. D. (2022). Scaffold Protein Lnx1 Stabilizes EphB Receptor Kinases for Synaptogenesis. Frontiers in Molecular Neuroscience, 15, 861873.

Jang, M., Park, R., Park, Y. I., Park, Y., Lee, J. I., Namkoong, S., ... & Park, J. (2021). LNX1 contributes to cell cycle progression and cisplatin resistance. Cancers, 13(16), 4066.

Baisiwala, S., Hall III, R. R., Saathoff, M. R., M. Shireman, J., Park, C., Budhiraja, S., ... & Ahmed, A. U. (2020). LNX1 modulates Notch1 signaling to promote expansion of the glioma stem cell population during temozolomide therapy in glioblastoma. Cancers, 12(12), 3505.

Bekri, A., Liao, M., & Drapeau, P. (2019). Glycine regulates neural stem cell proliferation during development via Lnx1-dependent Notch signaling. Frontiers in molecular neuroscience, 12, 44.

Park, R., Kim, H., Jang, M., Jo, D., Park, Y. I., Namkoong, S., ... & Park, J. (2019). LNX1 contributes to tumor growth by down‐regulating p53 stability. The FASEB Journal, 33(12), 13216-13227.

de La Rocha-Muñoz, A., Núñez, E., Arribas-González, E., López-Corcuera, B., Aragón, C., & de Juan-Sanz, J. (2019). E3 ubiquitin ligases LNX1 and LNX2 are major regulators of the presynaptic glycine transporter GlyT2. Scientific Reports, 9(1), 14944.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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