Mouse Anti-LPIN2 Recombinant Antibody (CBYJL-1924) (CBMAB-L1965-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lipin 2 (LPIN2). The antibody can be used for immunoassay techniques, such as WB.
See all LPIN2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-1924

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Synthetic peptide corresponding to the middle region of human LPIN2.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

lipin 2

Introduction

Mouse studies suggest that LPIN2 functions during normal adipose tissue development and may play a role in human triglyceride metabolism. LPIN2 represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance.

Entrez Gene ID

9663

UniProt ID

Q92539

Alternative Names

phosphatidate phosphatase LPIN2; EC 3.1.3.4

Function

Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Plays important roles in controlling the metabolism of fatty acids at different levels. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.

Biological Process

Cellular lipid metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular response to insulin stimulusManual Assertion Based On ExperimentIBA:GO_Central
Fatty acid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Triglyceride biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Cytoplasm, cytosol
Endoplasmic reticulum membrane
Translocates to endoplasmic reticulum membrane with increasing levels of oleate.

Involvement in disease

Majeed syndrome (MJDS):
An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).

References

Badiger, V. A., Balan, S., Madan, S., Gogineni, K. S., Shah, H., & Narayanan, D. L. (2024). LPIN2-related Majeed syndrome: report of two Indian patients with novel variants in LPIN2 and review of literature. Clinical Dysmorphology, 33(1), 27-30.

Bhuyan, F., de Jesus, A. A., Mitchell, J., Leikina, E., VanTries, R., Herzog, R., ... & Goldbach‐Mansky, R. (2021). Novel Majeed Syndrome–Causing LPIN2 Mutations Link Bone Inflammation to Inflammatory M2 Macrophages and Accelerated Osteoclastogenesis. Arthritis & Rheumatology, 73(6), 1021-1032.

Hu, X., Zhao, Z., Guo, R., Guo, J., Li, W., Hao, C., & Xu, B. (2019). Compound heterozygous LPIN2 pathogenic variants in a Majeed Syndrome patient with recurrent fever and severe neutropenia: case report.

Liu, J., Hu, X. Y., Zhao, Z. P., Guo, R. L., Guo, J., Li, W., ... & Xu, B. P. (2019). Compound heterozygous LPIN2 pathogenic variants in a patient with Majeed syndrome with recurrent fever and severe neutropenia: case report. BMC medical genetics, 20(1), 1-5.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-LPIN2 Recombinant Antibody (CBYJL-1926)

Mouse Anti-LPIN2 Recombinant Antibody (CBYCL-440)

Mouse Anti-LPIN2 Recombinant Antibody (2518C6a)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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