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Mouse Anti-LRG1 Recombinant Antibody (CBYCL-455) (CBMAB-L0356-YC)

Provided herein is a Mouse monoclonal antibody against Rat LRG1. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all LRG1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBYCL-455
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Leucine Rich Alpha-2-Glycoprotein 1
Specificity
Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH7.4, with 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LRG1
Introduction
LRG1 has been shown to be involved in promoting neovascularization (new blood vessel growth) through causing a switch in transforming growth factor beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway.
Entrez Gene ID
367455
UniProt ID
Q5I0E1
Alternative Names
HMFT1766; LRG
Biological Process
Brown fat cell differentiationIEA:Ensembl
Keratinocyte migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Leukocyte adhesion to vascular endothelial cellManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of epithelial cell proliferation involved in wound healingManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Response to bacteriumIEA:Ensembl
Wound healing, spreading of epidermal cellsManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Secreted

Grzesiak, L., Amaya-Garrido, A., Feuillet, G., Malet, N., Swiader, A., Sarthou, M. K., ... & Laffargue, M. (2023). Leucine-Rich Alpha-2 Glycoprotein 1 Accumulates in Complicated Atherosclerosis and Promotes Calcification. International Journal of Molecular Sciences, 24(22), 16537.

Sarkar, A., Chakraborty, D., Kumar, V., Malhotra, R., & Biswas, S. (2022). Upregulation of leucine-rich alpha-2 glycoprotein: A key regulator of inflammation and joint fibrosis in patients with severe knee osteoarthritis. Frontiers in Immunology, 13, 1028994.

Zou, Y., Xu, Y., Chen, X., Wu, Y., Fu, L., & Lv, Y. (2022). Research progress on leucine-rich alpha-2 glycoprotein 1: a review. Frontiers in pharmacology, 12, 809225.

Lin, M., Liu, J., Zhang, F., Qi, G., Tao, S., Fan, W., ... & Zhou, F. (2022). The role of leucine-rich alpha-2-glycoprotein-1 in proliferation, migration, and invasion of tumors. Journal of Cancer Research and Clinical Oncology, 1-9.

Liu, J. J., Pek, S. L., Liu, S., Wang, J., Lee, J., Ang, K., ... & Lim, S. C. (2021). Association of plasma leucine-rich alpha-2 glycoprotein 1 (LRG1) with all-cause and cause-specific mortality in individuals with type 2 diabetes. Clinical Chemistry, 67(12), 1640-1649.

Javaid, F., Pilotti, C., Camilli, C., Kallenberg, D., Bahou, C., Blackburn, J., ... & Chudasama, V. (2021). Leucine-rich alpha-2-glycoprotein 1 (LRG1) as a novel ADC target. RSC chemical biology, 2(4), 1206-1220.

Nambu, M., Masuda, T., Ito, S., Kato, K., Kojima, T., Daiko, H., ... & Ohtsuki, S. (2019). Leucine-rich alpha-2-glycoprotein 1 in serum is a possible biomarker to predict response to preoperative chemoradiotherapy for esophageal cancer. Biological and Pharmaceutical Bulletin, 42(10), 1766-1771.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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