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Mouse Anti-LRP8 Recombinant Antibody (CBLNA-174) (CBMAB-1599-CN)

This product is a mouse antibody that recognizes LRP8 of human. The antibody CBLNA-174 can be used for immunoassay techniques such as: WB, IF, FC.
See all LRP8 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBLNA-174
Antibody Isotype
IgG1, Κ
Application
WB, IF, FC

Basic Information

Immunogen
Recombinant fragment, corresponding to aa. 83-171 of Human ApoER2
Specificity
Human, Rat
Antibody Isotype
IgG1, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Introduction
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. The protein may also function as an endocytic receptor.
Entrez Gene ID
Human7804
Rat362558
UniProt ID
HumanQ14114
RatD3ZE75
Alternative Names
MCI1; LRP-8; APOER2; HSZ75190
Function
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands (PubMed:20223215).
LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity).
Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity).
(Microbial infection) Acts as a receptor for Semliki Forest virus.
Biological Process
Ammon gyrus developmentISS:BHF-UCL
Cellular response to cholesterolIEA:Ensembl
Cellular response to growth factor stimulusIEA:Ensembl
Chemical synaptic transmissionIEA:Ensembl
Cytokine-mediated signaling pathway1 PublicationNAS:UniProtKB
Dendrite morphogenesisIEA:Ensembl
EndocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Layer formation in cerebral cortexIEA:Ensembl
Lipid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Modulation of chemical synaptic transmissionISS:BHF-UCL
Positive regulation of CREB transcription factor activityISS:BHF-UCL
Positive regulation of dendrite developmentISS:BHF-UCL
Positive regulation of dendritic spine morphogenesisISS:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:BHF-UCL
Positive regulation of protein tyrosine kinase activityISS:BHF-UCL
Proteolysis1 PublicationNAS:UniProtKB
Reelin-mediated signaling pathwayISS:BHF-UCL
Regulation of apoptotic processISS:UniProtKB
Regulation of innate immune responseISS:UniProtKB
Response to xenobiotic stimulusIEA:Ensembl
Retinoid metabolic processTAS:Reactome
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Ventral spinal cord developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Secreted
Isoforms that contain the exon coding for a furin-type cleavage site are proteolytically processed, leading to a secreted receptor fragment.
Involvement in disease
Myocardial infarction 1 (MCI1):
A condition defined by the irreversible necrosis of heart muscle secondary to prolonged ischemia.
Topology
Extracellular: 42-826
Helical: 827-847
Cytoplasmic: 848-963
PTM
O-glycosylated. Some alternatively spliced isoforms lack the O-linked sugar domain (By similarity).
Undergoes sequential, furin and gamma-secretase dependent, proteolytic processing, resulting in the extracellular release of the entire ligand-binding domain as a soluble polypeptide and in the intracellular domain (ICD) release into the cytoplasm. The gamma-secretase-dependent proteolytical processing occurs after the bulk of the extracellular domain has been shed, in a furin-dependent manner, in alternatively spliced isoforms carrying the furin cleavage site. Hypoglycosylation (mainly hypo-O-glycosylation) leads to increased extracellular cleavage, which in turn results in accelerating release of the intracellular domain (ICD) by the gamma-secretase. The resulting receptor fragment is able to inhibit Reelin signaling and in particular the Reelin-induced DAB1 phosphorylation (By similarity).
Tyrosine phosphorylated upon apoE binding.
Ubiquitinated by MYLIP leading to degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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