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Mouse Anti-LRRC34 Recombinant Antibody (3F11) (CBMAB-L2112-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing 34 (LRRC34). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LRRC34 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
LRRC34 (NP_699184.1, 1 a.a. ~ 419 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MGSSREAARA PARSPAWAST QASTPGAALA VQRESPESGL QKHYSNLCME KSQKINPFIL HILQEVDEEI KKGLAAGITL NIAGNNRLVP VERVTGEDFW ILSKILKNCL YINGLDVGYN LLCDVGAYYA AKLLQKQLNL IYLNLMFNDI GPEGGELIAK VLHKNRTLKY LRMTGNKIEN KGGMFFAAML QINSSLEKLD LGDCDLEEST VHVGRMLKEN HCLVALHMCK HDIKNSGIQQ LCDALYLNSS LRYLDVSCNK ITHDGMVYLA DVLKSNTTLE VIDLSFNRIE NAGANYLSET LTSHNRSLKA LSVVSNNIEG EGLVALSQSM KTNLTFSHIY IWGNKFDEAT CITYSDLIQM GCLKPDNTDV EPFVVDGRVY LAEVSNGLKK HYYWTSTYGE SYDHSSNAGF ALVPVGQQP.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-419

Target

Full Name
leucine rich repeat containing 34
Introduction
An important paralog of this gene is LRRC74B.
Entrez Gene ID
UniProt ID
Alternative Names
leucine-rich repeat-containing protein 34
Function
Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cellular Location
Nucleus
Nucleus, nucleolus
Cytoplasm
As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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