Mouse Anti-LRRC3B Recombinant Antibody (CBYJL-2011) (CBMAB-L2115-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing 3B (LRRC3B). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LRRC3B antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYJL-2011

Antibody Isotype

IgG1

Application

ELISA, WB

Basic Information

Immunogen

Recombinant protein corresponding to aa 28-205 from human LRRC3B, CHO-derived (UniProt # Q96PB8).

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 28-205

Target

Full Name

Leucine Rich Repeat Containing 3B

Introduction

LRRC3B is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been described for this gene.

Entrez Gene ID

116135

UniProt ID

Q96PB8

Alternative Names

LRP15; leucine-rich repeat-containing protein 3B; leucine-rich repeat protein LRP15

Cellular Location

Membrane

Topology

Helical: 205-225

References

Luo, L., Fu, S., Du, W., He, L. N., Zhang, X., Wang, Y., ... & Hong, S. (2023). LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy. Frontiers in Immunology, 14, 959868.

Wang, Y. (2021). LRRC3B polymorphisms contributed to breast cancer susceptibility in Chinese Han Population. Frontiers in Oncology, 11, 657168.

Boer, C. G., Chavez-Chavez, S. O., Uitterlinden, A. G., & van Meurs, J. B. (2020). Genome-wide association study of widespread pain links LRRC3B as possible novel pain associated gene. Osteoarthritis and Cartilage, 28, S128.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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