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Mouse Anti-LSM4 Recombinant Antibody (8A10) (CBMAB-L2219-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Lsm4 Homolog U6 Small Nuclear Rna And Mrna Degradation Associated (LSM4). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LSM4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8A10
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
LSM4 (NP_036453.1, 1aa -73aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-73

Target

Full Name
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Introduction
LSM4 is a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may function in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene.
Entrez Gene ID
25804
UniProt ID
Q9Y4Z0
Alternative Names
GRP; YER112W
Function
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166).
The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320).
Biological Process
mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Nuclear-transcribed mRNA catabolic processIEA:InterPro
P-body assemblyManual Assertion Based On ExperimentIBA:GO_Central
RNA splicingManual Assertion Based On ExperimentTAS:ProtInc
Spliceosomal snRNP assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Li, H., Ju, Y., Liu, W. W., Ma, Y. Y., Ye, H., & Li, N. (2023). Phase Separation of Purified Human LSM4 Protein. Molecular Biology, 57(1), 127-135.

Agrofoglio, Y. C., Iglesias, M. J., Perez-Santangelo, S., de Leone, M. J., Koester, T., Catala, R., ... & Mateos, J. L. (2023). Antagonistic effects of arginine methylation of LSM4 on alternative splicing during plant stress responses. bioRxiv, 2023-12.

Sun, Z. P., Tan, Z. G., & Peng, C. (2022). Long noncoding RNA LINC01419 promotes hepatocellular carcinoma malignancy by mediating miR‐485‐5p/LSM4 axis. The Kaohsiung Journal of Medical Sciences, 38(9), 826-838.

Chen, L., Lin, Y. H., Liu, G. Q., Huang, J. E., Wei, W., Yang, Z. H., ... & Yu, H. Z. (2022). Clinical significance and potential role of LSM4 overexpression in hepatocellular carcinoma: an integrated analysis based on multiple databases. Frontiers in Genetics, 12, 804916.

Wang, S., Jiang, C., He, C., Shen, D., Zhang, H., Zheng, Y., ... & Niu, D. (2022). AtMC1 negatively regulates immunity through modulating pre-mRNA splicing and miRNA accumulation, involving LSM4. Authorea Preprints.

Hou, W., & Zhang, Y. (2021). Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184. Pathology-Research and Practice, 217, 153275.

Yin, J., Lin, C., Jiang, M., Tang, X., Xie, D., Chen, J., & Ke, R. (2021). CENPL, ISG20L2, LSM4, MRPL3 are four novel hub genes and may serve as diagnostic and prognostic markers in breast cancer. Scientific reports, 11(1), 15610.

Wang, S., Xue, M., He, C., Shen, D., Jiang, C., Zhao, H., & Niu, D. (2021). AtMC1 associates with LSM4 to regulate plant immunity through modulating pre-mRNA splicing. Molecular Plant-Microbe Interactions, 34(12), 1423-1432.

Yin, J., Lin, C., Tang, X., Xie, D., Chen, J., & Ke, R. (2020). CENPL, ISG20L2, LSM4 and MRPL3 Are Four Novel Hub Genes Involved in Breast Cancer Development and Progression.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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