Mouse Anti-LTF Recombinant Antibody (A950) (CBMAB-AP4191LY)

lactotransferrin

LF; HLF2; GIG12; HEL110

MUB2002P

Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Antifungal humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIMP:UniProtKB
Bone morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIMP:UniProtKB
Defense response to Gram-positive bacteriumIMP:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIMP:UniProtKB
Innate immune response in mucosaManual Assertion Based On ExperimentIDA:UniProtKB
Iron ion homeostasisIEA:UniProtKB-KW
Iron ion transportManual Assertion Based On ExperimentIBA:GO_Central
Killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Membrane disruption in another organismManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation by host of viral processManual Assertion Based On ExperimentIMP:AgBase
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of ATP-dependent activityManual Assertion Based On ExperimentIMP:AgBase
Negative regulation of cysteine-type endopeptidase activityManual Assertion Based On ExperimentIDA:CAFA
Negative regulation of lipopolysaccharide-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of membrane potentialIMP:UniProtKB
Negative regulation of osteoclast developmentISS:UniProtKB
Negative regulation of single-species biofilm formation in or on host organismManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tumor necrosis factor (ligand) superfamily member 11 productionISS:UniProtKB
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIMP:AgBase
Negative regulation of viral processManual Assertion Based On ExperimentIMP:AgBase
OssificationIEA:UniProtKB-KW
Positive regulation of bone mineralization involved in bone maturationISS:UniProtKB
Positive regulation of chondrocyte proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of osteoblast differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of osteoblast proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of protein serine/threonine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of toll-like receptor 4 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB

Isoform 1:
Secreted
Cytoplasmic granule
Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
Isoform DeltaLf:
Cytoplasm
Nucleus
Mainly localized in the cytoplasm.

Isoform DeltaLf
Phosphorylation at Ser-10 activates the transcriptional activity (PubMed:20404350).
Phosphorylation at Ser-10 also promotes proteasomal degradation (PubMed:20404350).
Alternatively can undergo O-GlcNAcylation at Ser-10 (PubMed:20404350).
Isoform DeltaLf
O-GlcNAcylation at Ser-10 inhibits DNA binding and negatively regulates the transcriptional activity (PubMed:20404350).
Alternatively can undergo phosphorylation at Ser-10 (PubMed:20404350).
Poly-N-acetyllactosaminic carbohydrate moiety seems to be needed for TLR4 activation.