Rat Anti-Ly6k Recombinant Antibody (mk34) (CBMAB-L2974-YJ)

Name: Rat Anti-Ly6k Recombinant Antibody (mk34)
SKU: CBMAB-L2974-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

mk34

Application

WB, IP, FC, IHC

Immunogen

Mouse testicular water-insoluble fraction.

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2, 50% Glycerol

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

lymphocyte antigen 6 family member K

Introduction

Ly6k is required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. It may play a role in cell growth (By similarity).

Entrez Gene ID

76486

UniProt ID

Q9CWP4

Alternative Names

mLy-6K; 2410015A16Rik; 3110035B01Rik; lymphocyte antigen 6K; ly-6K

Function

Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity).
May play a role in cell growth (PubMed:18089789).

Biological Process

Binding of sperm to zona pellucidaManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Cytoplasm
Cell membrane
Cytoplasmic vesicle, secretory vesicle, acrosome
Membrane raft

Park, S., Park, D., Han, S., Chung, G. E., Soh, S., Ka, H. I., ... & Yang, Y. (2023). LY6K depletion modulates TGF‐β and EGF signaling. Cancer Medicine.

Selvanesan, B. C., Varghese, S., Andrys-Olek, J., Arriaza, R. H., Prakash, R., Tiwari, P. B., ... & Upadhyay, G. (2023). Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction. Cancer Letters, 558, 216094.

Guo, D., Liu, Y., Jiang, Y., Zheng, S., Xu, T., Zhu, J., ... & Zhang, Y. (2022). A narrative review of the emerging role of lymphocyte antigen 6 complex locus K in cancer: from basic research to clinical practice. Annals of Translational Medicine, 10(1).

Geng, L., Wang, Z., & Tian, Y. (2022). Down-regulation of ZNF252P-AS1 alleviates ovarian cancer progression by binding miR-324-3p to downregulate LY6K. Journal of Ovarian Research, 15(1), 1-15.

Sastry, N. G., Wan, X., Huang, T., Alvarez, A. A., Pangeni, R. P., Song, X., ... & Cheng, S. Y. (2020). LY6K promotes glioblastoma tumorigenicity via CAV-1–mediated ERK1/2 signaling enhancement. Neuro-oncology, 22(9), 1315-1326.

Benti, S., Tiwari, P. B., Goodlett, D. W., Daneshian, L., Kern, G. B., Smith, M. D., ... & Upadhyay, G. (2020). Small molecule binds with lymphocyte antigen 6K to induce cancer cell death. Cancers, 12(2), 509.

Son, D., Kong, H. K., Kim, Y., Song, M. J., Kim, H. P., Lee, H. W., & Park, J. H. (2019). Transgenic overexpression of human LY6K in mice suppresses mature T cell development in the thymus. Oncology Letters, 17(1), 379-387.

Upadhyay, G. (2019). Emerging role of lymphocyte antigen-6 family of genes in cancer and immune cells. Frontiers in immunology, 10, 819.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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