Mouse Anti-LYL1 Recombinant Antibody (CBYJL-2227) (CBMAB-L2475-YJ)

Name: Mouse Anti-LYL1 Recombinant Antibody (CBYJL-2227)
SKU: CBMAB-L2475-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJL-2227

Application

WB, IP, IF, IHC-P, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

LYL1

Introduction

Gene of LYL1 represents a basic helix-loop-helix transcription factor. LYL1 may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia.

Entrez Gene ID

4066

UniProt ID

P12980

Alternative Names

bHLHa18; protein lyl-1; class A basic helix-loop-helix protein 18; lymphoblastic leukemia associated hematopoiesis regulator 1; lymphoblastic leukemia derived sequence 1

Biological Process

B cell differentiationISS:UniProtKB
Blood vessel maturationManual Assertion Based On ExperimentIMP:UniProtKB
Definitive hemopoiesisISS:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Nucleus

Involvement in disease

A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Sang, X., Zhang, Y., Fang, F., Gao, L., Tao, Y., Li, X., ... & Hu, S. (2022). BRD4 inhibitor GNE-987 exerts anticancer effects by targeting super-enhancer-related gene LYL1 in acute myeloid leukemia. Journal of Immunology Research, 2022.

Fang, F., Lu, J., Sang, X., Tao, Y. F., Wang, J. W., Zhang, Z. M., ... & Pan, J. (2022). Super-enhancer profiling identifies novel critical and targetable cancer survival gene LYL1 in pediatric acute myeloid leukemia. Journal of Experimental & Clinical Cancer Research, 41(1), 1-16.

Chen, Q., Cevher, M. A., Jiang, Q., Wang, S., Sun, X., Roeder, R. G., & Chen, M. (2022). LYL1 facilitates AETFC assembly and gene activation by recruiting CARM1 in t (8; 21) AML. Proceedings of the National Academy of Sciences, 119(42), e2213718119.

Wang, S., Ren, D., Arkoun, B., Kaushik, A. L., Matherat, G., Lécluse, Y., ... & Godin, I. (2021). Lyl-1 regulates primitive macrophages and microglia development. Communications biology, 4(1), 1382.

Murre, C. (2019). Helix–loop–helix proteins and the advent of cellular diversity: 30 years of discovery. Genes & development, 33(1-2), 6-25.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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